Search for Prognostic Factors in Head and Neck Cancer

Kraxner, Helga; Tamás, László; Járay, Balázs; Ribári, O; Szentirmay, Zoltán; Szende, B.

doi:10.3109/00016489709124059

Cited by 8 publications

(5 citation statements)

References 3 publications

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“…The pattern and relevance of radiationinduced apoptosis in nonhematological tumors has not been well studied. Our finding of no significant levels of apoptosis induced after 2 Gy supports the results of a study on 15 patients with advanced head and neck cancers [19]. In contrast, preliminary results of a study on solid pediatric tumors suggest that the level of apoptosis induced in vitro after 2 Gy has prognostic value [20].…”

Section: Discussionsupporting

confidence: 57%

“…A correlation was reported between AI following irradiation with 2 or 10 Gy in vitro and clinical response for patients with non-Hodgkin's lymphoma [18]. Another study on 15 patients with squamous cell carcinoma of the head and neck showed that the level of apoptosis induced following 2 Gy irradiation was low and not prognostic for radiotherapy outcome [19]. In contrast, preliminary results of in vitro radiation-induced apoptosis after 2 Gy measured as a proportion of pretreatment apoptosis was reported as having prognostic value for pediatric solid tumors [20].…”

Section: Introductionmentioning

confidence: 99%

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Tumor apoptosis in cervical cancer: Its role as a prognostic factor in 42 radiotherapy patients

Kim

Cho

Lee

et al. 2001

Intl Journal of Cancer

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SUMMARY To investigate tumor apoptosis as a prognostic factor for outcome following radiation therapy, comparisons were made of apoptotic index (AI) as a predictor of shortvs. long-term response and pretreatment vs. radiation-induced apoptosis. Forty-two patients with proven squamous cell carcinoma of the uterine cervix were treated by radiation alone. Apoptosis was measured by light microscopic observation of hematoxylin and eosinstained sections from biopsies taken before treatment and 4 and 24 hr after 2 Gy. Patients were evaluated at the end of the external radiation for determination of short-term response and for long-term outcome as well (median follow-up of 27 months). Patients with high spontaneous AI showed poor short-term response, local control, and survival. The significance of AI as a predictor of short-term response was lost after allowing for differences in tumor size. The positive predictive value of AI for local control and survival was independent of tumor size and stage. High AI was associated with poor local control and long-term prognosis in advanced squamous cell carcinoma of the cervix. The in vivo radiation-induced AI after 4 or 24 hr did not predict radiation therapy outcome.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Tumor apoptosis in cervical cancer: Its role as a prognostic factor in 42 radiotherapy patients

Kim

Cho

Lee

et al. 2001

Intl Journal of Cancer

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“…Mean age was 66.1 years (range, 49-83 years) in the good survival group, and 72.6 years (range, 59-84 years) in the poor survival group (P=0.09). The mean dose of irradiation within the first week was 12.4 Gy (range, [9][10][11][12][13][14] in the good survival group, and 11.3 Gy (range, [9][10][11][12][13][14] in the poor survival group (P=0. 19).…”

Section: Patients and Radiation Therapymentioning

confidence: 99%

“…6) Spontaneous apoptosis is a mechanism of cell loss in untreated tumors, 3) so irradiation probably enhances the process of apoptosis that results in tumor cell death in irradiated patients. [7][8][9] In human uterine cervical cancer, Ohno et al recently reported the induction of apoptosis and an apoptosisrelated protein, Bax, after irradiation therapy. 10) However, no data are available that indicate whether the induction of apoptosis in uterine cervical cancer tissue after the initial dose of irradiation therapy predicts the long-term prognosis of irradiated patients.…”

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confidence: 99%

Detection of Apoptosis and Expression of Apoptosis‐associated Proteins as Early Predictors of Prognosis after Irradiation Therapy in Stage IIIb Uterine Cervical Cancer

Yuki

Fujimura

Yamakawa

et al. 2000

Japanese Journal of Cancer Research

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We investigated the proportion of apoptotic cells and the expression of apoptosis-associated proteins after the delivery of the first week of irradiation for stage IIIb uterine cervical cancer. Thirty patients with stage IIIb squamous cell carcinoma of the uterine cervix who received only irradiation therapy were registered in this study. Specimens were obtained before irradiation therapy and at the end of the first week of irradiation. The apoptotic index (AI) of each tissue specimen was calculated by counting the apoptotic cells and expressed as a percentage. Immunohistochemical evaluation for apoptosis-related proteins, p53, Bcl-2, Bax, caspase-1 and caspase-3 was also performed. The AI was 0.8 ± ± ± ±0.9% (mean ± ± ± ± SD) before irradiation and 1.7 ± ± ± ±1.3% at the end of the first week of irradiation. We observed that the patients who survived more than 5 years had AI levels of 2.1 ± ± ± ±1.3% at the end of their first week of therapy. This rate was significantly higher than the rate of 1.1 ± ± ± ±0.8% (P = = = =0.02) of the patients who died within 5 years. When the cut-off value of the AI was set at 1.7%, the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of patients' prognosis after irradiation therapy were 73.4%, 72.4%, 82.4%, and 61.5%, respectively. In 17 of the AI-positive cases, expressions of Bax (P = = = =0.006), caspase-1 (P = = = =0.045), and caspase-3 (P = = = =0.013) at the end of the first week were significantly higher than before irradiation. The proportion of apoptotic cells and the expression of apoptosis-associated proteins, Bax, caspase-1, and caspase-3, at the end of the first week of irradiation could be useful predictors of the prognosis in stage IIIb squamous cell carcinoma of the uterine cervix treated by irradiation therapy.

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“…10,11 For example, studies [12][13][14] revealed that a higher MI value is predictive for local tumor recurrence, patient survival time, and treatment response in humans with cervical SCC. In another study, 15 some human patients with head and neck SCC who had reduction of MI after the first fraction of radiation therapy had longer survival time than did patients who had increased MI. Due to the similarities between human and feline oral SCC, 16 MI could be of prognostic importance in cases of oral SCC in cats.…”

mentioning

confidence: 96%

Immunohistochemical characterization of feline oral squamous cell carcinoma

Yoshikawa

Ehrhart²,

Charles³

et al. 2012

ajvr

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Results suggested that EGFR expression might be a valuable prognostic factor for treatment outcome in feline oral SCC. It also identified higher angiogenesis in tongue SCC, compared with mandibular and maxillary SCC, which may account for a different clinical outcome. Further prospective characterization of feline oral SCC may provide a better understanding of the underlying molecular factors that drive its behavior and offer the possibility for future patient-specific treatment plans.

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Search for Prognostic Factors in Head and Neck Cancer

Cited by 8 publications

References 3 publications

Tumor apoptosis in cervical cancer: Its role as a prognostic factor in 42 radiotherapy patients

Tumor apoptosis in cervical cancer: Its role as a prognostic factor in 42 radiotherapy patients

Detection of Apoptosis and Expression of Apoptosis‐associated Proteins as Early Predictors of Prognosis after Irradiation Therapy in Stage IIIb Uterine Cervical Cancer

Immunohistochemical characterization of feline oral squamous cell carcinoma

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