To explain the observed muon anomaly and simultaneously evade bounds from lepton flavor violation in the same model parameter space is a long-cherished dream. In view of a generalized Two Higgs Doublet Model, with a Yukawa structure as a perturbation of Type-X, we are able to get substantial parameter space satisfying these criteria. In this work, we focus on a region with “wrong-sign” lepton-Yukawa coupling which gives rise to interesting phenomenological consequences. Performing a simple cut-based analysis, we show that at 14 TeV run of the LHC with $$300 \mathrm{{fb}}^{-1}$$
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integrated luminosity, part of the model parameter space can be probed with significance "Equation missing" which further improves with Artificial Neural Network analysis.