Search for germinal mutations in insulin-producing pancreatic tumors
M. Yu. Yukina,
E. A. Troshina,
N. F. Nuralieva
et al.
Abstract:BACKGROUND: It is known that insulinoma in approximately 5% of cases is associated with multiple endocrine neoplasia type 1 syndrome (MEN1), in which the prognosis and management tactics of patients have been developed in detail. The diagnosis of MEN1 often does not require genetic confirmation, since the syndrome has a typical clinical picture. At the same time, a combination of this tumor with other hereditary syndromes is found in the literature, which are characterized by the presence of malignant neoplasm… Show more
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