Search for genetic loci involved in the constitution and skin type of a Japanese women using a genome‐wide association study

Abstract

The constitution and skin type of individuals are influenced by various factors. Recently, the influence of genetic predispositions on these has been emphasized. To date, genome‐wide association studies (GWAS) have shown several single nucleotide polymorphisms (SNPs) that affect individual's constitution and skin type. However, these studies have mainly focused on the Caucasian population, and only a few association analyses with the constitution and skin type of individuals involving a Japanese population have been conducted. In this study, we conducted a GWAS analysis of 9 phenotypes regarding the constitution or skin type of 1108 Japanese women based on a questionnaire. As a result, in addition to SNPs known to be involved in phenotypes in the past, we discovered new SNPs and genetic regions related to darkness of pigmented spots, skin flushing, frequency of rough skin and responsiveness to cosmetics.

A systematic review of skin ageing genes: gene pleiotropy and genes on the chromosomal band 16q24.3 may drive skin ageing

“…The detailed breakdown and definitions used are in Supplementary Table S3 . Briefly, nineteen papers defined the phenotype by describing the appearance of the feature 15 , 33 , 48 , 49 , 52 – 54 , 57 – 68 , three papers employed image analysis algorithms to identify the feature 56 , 57 , 69 , fourteen papers identified the feature using photonumeric scales 14 , 45 , 47 , 51 , 52 , 57 , 69 – 76 , seven papers detected the feature through self-reporting via questionnaires 46 , 50 , 67 , 76 – 79 , three papers detected the feature through equipment 55 , 80 , 81 , two papers studied genomic data collected for a different condition (e.g. the inability to tan) and attempted to use it for their phenotype (e.g., carcinoma) 54 , 82 , and the way that the feature was defined was not reported in five papers 30 , 33 , 61 , 83 , 84 .…”

Analysis of the effect of daily stress on the skin and search for genetic loci involved in the perceived stress of an individual

“…The subjects were healthy adults (1200 females living in Japan) from whom written informed consent regarding study participation was obtained. They were similar to those enroled in our previous study 12 . Prior to this study, its protocol was approved by the Ethics Review Board of our company.…”

“…They were similar to those enroled in our previous study. 12 Prior to this study, its protocol was approved by the Ethics Review Board of our company.…”

“…Genome data were collected from the subjects, as previously described. 12 Briefly, saliva was collected from each subject using a saliva sampling kit (Genesis Healthcare). Genome DNA was extracted using a Maxwell RSC Stabilised Saliva DNA Kit (Promega).…”

A systematic review of skin ageing genes reveals a pleiotropic landscape where skin colour genes and chromosomal band 16q24.3 genes may drive skin ageing

“…The detailed breakdown and de nitions used are in Supplementary Table S3. Brie y, nineteen papers de ned the phenotype by describing the appearance of the feature 10,29,44,45,48,50,51,[54][55][56][57][58][59][60][61][62][63][64][65] , three papers employed image analysis algorithms to identify the feature 53,54,66 , fourteen papers identi ed the feature using photonumeric scales 41,43,[47][48][49]54,[66][67][68][69][70][71][72][73] , seven papers detected the feature through self-reporting via questionnaires 42,46,62,70,[74][75][76] , three papers detected the feature through equipment 52,77,78 , two papers studied genomic data collected for a different condition (e.g. the inability to tan) and attempted to use it for their phenotype (e.g., carcinoma) 51,79 , a...…”