Recently, Jenkins, et al. have reported the detection of correlations between fluctuations in nuclear decay rates and Earth-Sun distance, which suggest that nuclear decay rates can be affected by solar activity. In this paper, we report the detection of a significant decrease in the decay of 54 Mn during the solar flare of 13 December 2006, whose x-rays were first recorded at 02:37 UT (21:37 EST on 12 December). Our detector was a 1 μCi sample of 54 Mn, whose decay rate exhibited a dip coincident in time with spikes in both the x-ray and proton fluxes recorded by the GOES-10 and 11 satellites. A secondary peak in the x-ray and proton fluxes on 17 December at 12:40 EST was also accompanied by a coincident dip in the 54 Mn decay rate. These observations support the claim by Jenkins, et al. that nuclear decay rates vary with Earth-Sun distance.Solar flares are periods of increased solar activity, and are often associated with geomagnetic storms, solar radiation storms, radio blackouts, and similar effects that are experienced here on Earth. It has been speculated that the increased activity associated with solar flares may also produce a short-term change in the neutrino flux detected on Earth. 1,2,3,4,5,6 To date, there appears to be no compelling experimental evidence of an association between neutrino flux and solar flares, 1,2,4,6 and this is due in part to the relatively low neutrino counting rates available from even the largest conventional detectors.The object of the present paper is to use data we obtained during the solar flare of 13 December 2006 to suggest that neutrinos from the flare were detected via the change they induced in the decay rate of 54 Mn. The present paper supports the work of Jenkins, et al. who present evidence for a correlation between nuclear decay rates and Earth-Sun distance 7 . Taken together, these papers suggest that nuclei may respond to changes in solar activity, possibly arising from changes in the flux of solar neutrinos reaching the Earth.The apparatus that was in operation during the solar flare is described in detail in the Supplemental Material. During the course of the data collection in the Physics building at Purdue University which extended from 2 December 2006 to 2 January 2007, a solar flare was detected on 13 December 2006 at 02:37 UT (21:37 EST on 12 December) by the Geostationary Operational Environmental Satellites (GOES-10 and GOES-11). Spikes in the x-ray and proton fluxes were recorded on all of the GOES satellites. (2)d -1 determined from our December data. We see from Figs. 1-3 that, to within the time resolution offered by the 4 hour width of our bins, the 54 Mn counting rates exhibit a dip which is coincident in time with the spike in the x-ray flux which signalled the onset of the solar flare. Although a second x-ray peak on 14 December at 17:15 EST corresponds to a relatively small dip in the 54 Mn count rate, a third peak on 17 December at 12:40 EST is again accompanied by an obvious dip in the 54 Mn counting rate, as seen in Figs.1-3. The fact that...