Search for Bactericides Among Derivatives of Deoxyvasicinone, Mackinazolinone, and Thienopyrimidinones

Ortikov, I. S.; Turdibaev, Zh. E.; Islamova, Zh. I.; Элмурадов, Б. Ж.; Abdurazakov, A. Sh.; Бектемиров, А. М.; Osipova, Svetlana; Хушбактова, З. А.; Сыров, В. Н.; Shakhidoyatov, Kh. M.

doi:10.1007/s11094-017-1633-0

Cited by 8 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, their thienopyridine analogues 71a and 71b only showed moderate antibacterial activity, which could suggest that the carbonyl group at position 4 is important for the activity. Similar thienopyrimidin-4ones 70a-b and thienopyrimidine-2,4-diones 69d-e were reported by Ortikov et al Compounds were evaluated in vitro (Table 15) against the three previous bacterial strains and against P. aeruginosa [11]. Globally, this series showed lower antibacterial efficacy than the previous series, suggesting that the presence of a benzoyl group at R1 is important for the activity (compare 69c to 69e).…”

Section: Compounds Wih Broad-spectrum Antibacterial Activitysupporting

confidence: 59%

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

et al. 2021

View full text Add to dashboard Cite

Thienopyrimidines are widely represented in the literature, mainly due to their structural relationship with purine base such as adenine and guanine. This current review presents three isomers—thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and thieno[3,4-d]pyrimidines—and their anti-infective properties. Broad-spectrum thienopyrimidines with biological properties such as antibacterial, antifungal, antiparasitic and antiviral inspired us to analyze and compile their structure–activity relationship (SAR) and classify their synthetic pathways. This review explains the main access route to synthesize thienopyrimidines from thiophene derivatives or from pyrimidine analogs. In addition, SAR study and promising anti-infective activity of these scaffolds are summarized in figures and explanatory diagrams. Ligand–receptor interactions were modeled when the biological target was identified and the crystal structure was solved.

show abstract

Section: Compounds Wih Broad-spectrum Antibacterial Activitysupporting

confidence: 59%

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The alkaloid mackinazolinone (2,3,4,10-tetrahydro-1 H -pyrido[2,1- b ]quinazolin-10-one) 68 , isolated from a species of Mackinlaya , was reported to undergo formylation using the Vilsmeier–Haack reaction to give formylated product 69 (Scheme 20 ). 51 52…”

Section: Formylationmentioning

confidence: 99%

“…50 The alkaloid mackinazolinone (2,3,4,10-tetrahydro-1Hpyrido[2,1-b]quinazolin-10-one) 68, isolated from a species of Mackinlaya, was reported to undergo formylation using the Vilsmeier-Haack reaction to give formylated product 69 (Scheme 20). 51,52 Boradiazaindacenes (BODIPY dyes) are strongly UV-absorbing molecules with high fluorescence quantum yields, sharp fluorescence emissions, high photophysical stability, and low sensitivity to the polarity and pH of their environment. 53 Jiao et al utilized the modified Vilsmeier-Haack reaction (using excess amounts of DMF/POCl 3 in refluxing 1,2-dichloroethane) for the synthesis of -formyl BODIPYs (boradiazaindacenes) 71 in 85-93% yields via formylation of tetramethyl-BODIPYs 70 at their -position.…”

Section: Cluster Account Synlettmentioning

confidence: 99%

Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis

Singh

Dohi

Kumar

et al. 2023

Synlett

View full text Add to dashboard Cite

The Vilsmeier–Haack reaction has historically been a topic of significant interest to organic chemists, and it continues to attract considerable attention. The reaction itself provides a facile route towards a large number of aromatic and heteroaromatic systems. The Vilsmeier–Haack reagent, generated from amides and halides, is found to be very important in organic synthesis. This account highlights recent developments in the synthetic utility of the Vilsmeier–Haack reagent.1 Introduction2 Formylation3 Formylation and Chlorination4 Formylation and Acetylation5 Chlorination6 ortho-Formylation7 Miscellaneous8 Conclusions

show abstract

Electrosynthesis of CF₃‐Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene

Liu

Zhang

et al. 2022

Adv Synth Catal

View full text Add to dashboard Cite

An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene with Langlois reagent as a CF 3 source is described. A variety of polycyclic quinazolinones were successfully synthesized in 52-81% yields under transition metal-and oxidant-free conditions. The Langlois reagent used in this strategy as a CF 3 reagent possesses the advantages of bench-stablity, cost-effectivity and high-efficiency. Additionally, gram-scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol.

show abstract

Search for Bactericides Among Derivatives of Deoxyvasicinone, Mackinazolinone, and Thienopyrimidinones

Cited by 8 publications

References 13 publications

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis

Electrosynthesis of CF₃‐Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene

Contact Info

Product

Resources

About

Search for Bactericides Among Derivatives of Deoxyvasicinone, Mackinazolinone, and Thienopyrimidinones

Cited by 8 publications

References 13 publications

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents

Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis

Electrosynthesis of CF3‐Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene

Contact Info

Product

Resources

About

Electrosynthesis of CF₃‐Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene