The LHCb experiment observed B + → π + µ + µ − decay with 1.0 fb −1 data, which is the first measurement of a flavor changing neutral current b → dℓ + ℓ − decay (ℓ = e, µ). Based on QCD factorization, we give Standard Model predictions for the branching ratios, direct CP asymmetries, and isospin asymmetry for B → πℓ + ℓ − decays, in the kinematic region where the dilepton invariant mass is small. We find that the contribution from weak annihilation enhances the direct CP asymmetry for low ℓ + ℓ − pair mass. Anticipating improved measurements, we assess the utility offor determining CKM parameters in the future. PACS numbers: 12.15.Hh 11.30.Er 13.20.He 1 As for B → K ( * ) ℓ + ℓ − /ρℓ + ℓ − , isospin asymmetries were also are of great interest even within SM because V * ud V ub carries CPV phase. In contrast, such effects are suppressed by V * us V ub for b → sℓ + ℓ − processes. The B → πℓ + ℓ − modes may also be used to probe New Physics, such as two Higgs doublet model [4, 5], R-parity violating supersymmetry [6], and fourth generation [18].This paper is a followup of the last paper, where some results were used in conjunction with the study of B d → µ + µ − mode. In this paper we focus on SM expectations for B → πℓ + ℓ − . After presenting the basic formulas and input parameters in Sec. II, the SM predictions are given in Sec. III. We discuss prospects for constraining CKM parameters in Sec. IV, before giving our conclusion. Some details are placed in Appendices. studied [16] employing light-cone sum rule to calculate matrix elements for weak annihilation and O 8 [in Eq. (4)] [17].