Search for Antiviral Agents Among Quinopimaric Acid Scaffold Derivatives

Vafina, G. F.; Uzbekov, A. R.; Zarubaev, V. V.; Karpinskaya, L. A.; Штро, Анна А.; Yunusov, M. S.

doi:10.1007/s10600-015-1212-0

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“…Dihydroquinopymaric acid amides and their 1β-succinyl and 1β-phthalyl derivatives containing amino acid residues show moderate activity against the reproduction of influenza virus A/FPV/Rostock/34 (H7N1) ( Flekhter et al, 2009 ), while quinopimaric acid derivatives with esters fragments are characterized by more pronounced antiviral properties against influenza A/California/07/09 (H1N1) with selectivity indices of 10 and greater. The conjugate with cinnamic acid shows the highest SI = 56.6 ( Vafina et al, 2015 ). Dihydroquinopimaric acid is found to be moderately active against influenza virus type A (H1N1) (EC 50 4.5; IC 50 >100; SI >22), whereas its oxidized product is moderately active against influenza virus type A (H1N1 and H3N2) (EC 50 3.2; IC 50 >100; SI >31 and EC 50 2.6; IC 50 >100; SI >38) and papilloma virus HPV-11 ( Kazakova et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%