Seamless Combination of High-Pressure Chip-HPLC and Droplet Microfluidics on an Integrated Microfluidic Glass Chip

Gerhardt, Renata; Peretzki, Andrea J.; Piendl, Sebastian K.; Belder, Detlev

doi:10.1021/acs.analchem.7b04331

Cited by 37 publications

(32 citation statements)

References 60 publications

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“…The application of microfluidics in food analysis has advantages including low reagent consumption, onsite testing, portable, and low cost. The most common microfluidic devices were made with silicon wafer, glass (Gerhardt, Peretzki, Piendl, & Belder, 2017), polymer (Hiltunen et al, 2018) or paper (Hamidon et al, 2018), the glass or polymer-based microfluidic usually requires complicated microchannel fabrication procedure (usually two for more layers), and bonding process for the enclosing of fabricated microchannels.…”

Section: Resultsmentioning

confidence: 99%

Milk carton with integrated paper‐based microfluidics for milk quality rapid test

Fan

Wang

Liu

et al. 2018

Journal of Food Safety

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This study integrated paper‐based microfluidic device on a milk carton for a rapid milk quality check. The microfluidic device was printed on the outer surface of milk carton using commercial wax printer. The testing process is fully automatic, after apply one drop of milk on the loading point, milk was driven by capillary force in the porous paper fiber in wax‐defined microchannels to reach the preload reactants for chromogenic reaction. The proposed integration method provides a simple, low cost and rapid onsite milk quality check technique for milk consumers, and also have wide potential applications in food industry. Practical applications Microfluidics has been widely used in the chemical and biological field for analysis or synthesis, in this research, the microfluidic devices were integrated on the outer surface of a milk carton for a rapid and low‐cost milk quality test, and the test result could be easily read using mobile phone app. The proposed research is of significant application prospect in food industry for rapid and onsite food quality test using the microfluidic devices integrated on paper packaging. The fabrication method of the microfluidic devices proposed in this research using wax printing is also low cost and nontoxic, and could be easily integrated with the current paper packaging production line.

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Section: Resultsmentioning

confidence: 99%

Milk carton with integrated paper‐based microfluidics for milk quality rapid test

Fan

Wang

Liu

et al. 2018

Journal of Food Safety

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“…To ensure a pressure-tight interface between the microchip and the fused-silica capillaries, in-house-built stainless-steel connection clamps consisting of perfluoro-elastomeric (FFKM) ferrules and headless 6-32 PEEK screws (N-123-04 and N-123H, IDEX Health & Science, USA), were used [31]. Microchip flow reactor The microfluidic glass chips were designed and fabricated in-house by common photolithography, wet-etching, and bonding methods [32]. A description is found in the Electronic Supplementary Material (ESM).…”

Section: Experimental Partmentioning

confidence: 99%

In situ monitoring of photocatalyzed isomerization reactions on a microchip flow reactor by IR-MALDI ion mobility spectrometry

et al. 2020

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The visible-light photocatalytic E/Z isomerization of olefins can be mediated by a wide spectrum of triplet sensitizers (photocatalysts). However, the search for the most efficient photocatalysts through screenings in photo batch reactors is material and time consuming. Capillary and microchip flow reactors can accelerate this screening process. Combined with a fast analytical technique for isomer differentiation, these reactors can enable high-throughput analyses. Ion mobility (IM) spectrometry is a cost-effective technique that allows simple isomer separation and detection on the millisecond timescale. This work introduces a hyphenation method consisting of a microchip reactor and an infrared matrix-assisted laser desorption ionization (IR-MALDI) ion mobility spectrometer that has the potential for high-throughput analysis. The photocatalyzed E/Z isomerization of ethyl-3-(pyridine-3-yl)but-2-enoate (E-1) as a model substrate was chosen to demonstrate the capability of this device. Classic organic triplet sensitizers as well as Ru-, Ir-, and Cu-based complexes were tested as catalysts. The ionization efficiency of the Z-isomer is much higher at atmospheric pressure which is due to a higher proton affinity. In order to suppress proton transfer reactions by limiting the number of collisions, an IM spectrometer working at reduced pressure (max. 100 mbar) was employed. This design reduced charge transfer reactions and allowed the quantitative determination of the reaction yield in real time. Among 14 catalysts tested, four catalysts could be determined as efficient sensitizers for the E/Z isomerization of ethyl cinnamate derivative E-1. Conversion rates of up to 80% were achieved in irradiation time sequences of 10 up to 180 s. With respect to current studies found in the literature, this reduces the acquisition times from several hours to only a few minutes per scan.

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“…The adhesion of NPs might be successfully reduced by segmented liquid‐liquid system . However, although there are promising works using segmented flow in separation system , SERS detection has not been so far reported.…”

Section: Experimental Considerations Of Using Sers As a Detector For mentioning

confidence: 99%

Combination of liquid‐based column separations with surface‐enhanced Raman spectroscopy

Týčová

Klepárnı́k

2018

J of Separation Science

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Surface‐enhanced Raman spectroscopy is a constantly developing analytical method providing not only high‐sensitive quantitative but also qualitative information on an analyte. Thus, it is reasonable that it has been tested as a promising detection method in column separations. Although its implementation in analytical separations is not widespread, some surprising results, like enormous signal enhancement and demonstrations of single‐molecule identifications, proved in only a few special examples, indicate the potential of the method. The high detection sensitivity and selectivity would be of paramount importance in trace analyses of biologically relevant molecules in complex matrices. However, the combination of surface‐enhanced Raman spectroscopy with column separation methods brings two principal issues. Interactions of analytes with metal substrates can cause deteriorations of separations and the detection can be affected by background electrolytes or elution agents. Thus, in principle, this review is on the experimental and methodological solutions to these problems. First, theoretical and practical aspects of Raman scattering, and excitation of surface plasmon in colloid suspensions of nanoparticles and on planar nanostructured substrates are briefly explained. Advances in experimental arrangements of on‐line and at‐line couplings with column liquid phase separation methods, including microfluidic devices, are described together with chosen analytical applications.

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Seamless Combination of High-Pressure Chip-HPLC and Droplet Microfluidics on an Integrated Microfluidic Glass Chip

Cited by 37 publications

References 60 publications

Milk carton with integrated paper‐based microfluidics for milk quality rapid test

Milk carton with integrated paper‐based microfluidics for milk quality rapid test

In situ monitoring of photocatalyzed isomerization reactions on a microchip flow reactor by IR-MALDI ion mobility spectrometry

Combination of liquid‐based column separations with surface‐enhanced Raman spectroscopy

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