Seabuckthorn Reverses High-Fat-Diet-Induced Obesity and Enhances Fat Browning via Activation of AMPK/SIRT1 Pathway

Abstract

Seabuckthorn possesses various bioactive compounds and exhibits several positive pharmacological activities. The present trial aims to determine the effect of seabuckthorn powder intake on high-fat diet (HFD)-induced obesity prevention in mice. The results suggest that seabuckthorn powder intake decreased body weight, fat mass, and circulating lipid levels, and improved insulin sensitivity in HFD-fed mice. Moreover, dietary seabuckthorn powder alleviated hepatic steatosis and hepatic lipid accumulation induced by the HFD. Furthermore, seabuckthorn exhibited obvious anti-inflammatory capacity in white adipose tissue (WAT) by regulating the abundance of inflammation-related cytokines, such as interleukins 4, 6, and 10; tumor necrosis factor α; and interferon-γ. More importantly, dietary seabuckthorn powder promoted a thermogenic program in BAT and induced beige adipocyte formation in iWAT in HFD-fed mice. Interestingly, we found that seabuckthorn powder effectively restored AMPK and SIRT1 activities in both BAT and iWAT in HFD-fed mice. Collectively, these results potentiate the application of seabuckthorn powder as a nutritional intervention strategy to prevent obesity and related metabolic diseases by promoting thermogenesis in BAT and improving beige adipocyte formation in WAT.

Mulberry and Hippophae‐based solid beverage attenuate hyperlipidemia and hepatic steatosis via adipose tissue–liver axis

“…As a result, plant‐based dietary supplements are growingly recognized to play an important role in the management of NAFLD, especially at its initial stage (Perumpail et al., 2018 ). For example, sea buckthorn is found to reverse obesity induced by a high‐fat diet and promote fat browning through the activation of AMPK/SIRT1 pathway (Wang et al., 2022 ). Interestingly, mulberry leaf has been previously shown to have hepatoprotective effect likely through regulating adipocytokines, inflammation, and oxidative stress in a high‐fat diet‐induced mice model of obesity and NAFLD (Ann et al., 2015 ; Peng et al., 2018 ).…”

“…Interestingly, mulberry leaf has been traditionally used as a herb for lowering blood glucose and lipids, consistent with its high content of flavonoids and alkaloids (Liu et al., 2023 ; Zhang et al., 2022 ). On the other hand, Hippophae protein peptides are functional ingredients from Hippophae rhamnoides L. seeds, which have been shown to enhance insulin sensitivity and reduce lipogenesis (Wang et al., 2022 ; Yuan et al., 2016 ). However, their protective potential against NAFLD and underlying mechanisms have yet to be fully elucidated.…”