Sea grapes powder with the addition of tempe rich in collagen: An anti-aging functional food

Abstract

Background: This study aimed to determine the potential anti-aging effects of sea grapes and tempe (fermented soybeans) collagen particle size, by measuring the activities of anti-glycation, antioxidant, and tyrosinase inhibitors. Methods: Collagen was isolated from freeze-dried sea grapes and tempe powder and treated with different NaOH concentrations (0.10 M; 0.20 M; 0.30 M), and CH3COOH 1 M solution, separately. The collagen particle size was adjusted by stirring at 1000 rpm for 5 and 10 hours. 2,2-diphenyl-1-picrylhydrazyl (DPPH) was used to measure the antioxidant activity, and L-tyrosine and L-DOPA (l-3,4-dihydroxyphenylalanine) was used as a marker of tyrosine inhibition. Results: The collagen treated with 0.10 M NaOH produced the highest collagen yield (11.65%), and the largest particle size (2455 nm). Additionally, this collagen, when treated for 5 hours, exhibited 24.70% antioxidant activity, 62.60% anti-glycation, 8.97% L-tyrosine, and 26.77% L-Dopa inhibition activities. Meanwhile, the collagen treated for 10 hours had a 9.98% antioxidant activity, 41.48% anti-glycation, 7.89% L-tyrosine, and 2.67% L-Dopa inhibition activity. Conclusion: Sea grapes and tempe collagen powder treated with 0.10 M NaOH and stirred for 5 hours, possess the best potential anti-aging properties as a functional food.

Metabolomic Assay, Computational Screening, and Pharmacological Evaluation of Caulerpa racemosa as an Anti-obesity With Anti-aging by Altering Lipid Profile and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α Levels

“…As Cheng et al (48) have pointed out, PGC-1α is an important factor in the regulation of lipid and metabolic processes (Figure 6) (48). Its role ranges from increasing heme oxygenase-1 (HO-1), which plays a role in inhibiting the incidence of reactive oxygen species (ROS) (49) along with antioxidants contained in sea grape extract to reducing advanced glycation end-product (AGE), oxidative stress from ultraviolet (UV) light and contribute to increasing inhibition of enzyme tyrosinase (L-Dopa) (50). This leads to the prevention of hyperpigmentation and depigmentation caused by UV rays (Figure 6) (51).…”

Algal-derived macromolecules and their composites: From synthetic biology to biomedical applications in bone and cardiovascular tissue engineering

“…In addition, red (Galaxaura oblongata, Corallina elongate, and Cystoseria compressa) and brown (C. compressa and Sargassum vulgare) algae powders have been successfully used and incorporated into polyhydroxyalkanoates, polycaprolactone, and polylactide to make potential biomaterials for the biomedical field (Sayin et al, 2020). They included Caulerpa racemosa, which has collagen properties, according to the latest study (Permatasari et al, 2022). Interestingly, polysaccharide derivatives or potential biopolymers such as chitin, fucoidans, sulfated fucans, sulfated l-fucose polysaccharide, carrageenans, sulfated galactan, laminaran, and alginate are abundant, even reaching 76% of the dry weight contained in macroalgae, mainly the Ulva, Ascophyllum, Palmaria, and Porphyra species (Zia et al, 2017;Azeem et al, 2017;El-Chaghaby and Rashad, 2021).…”

Dietary Supplementation of Caulerpa racemosa Ameliorates Cardiometabolic Syndrome via Regulation of PRMT-1/DDAH/ADMA Pathway and Gut Microbiome in Mice

“…Consumption of food rich in polyphenols and other antioxidant molecules may attenuate cardiometabolic syndrome [ 11 ]. Previous studies on C. racemosa have reported anti-obesity and antiaging effects through the modulation of blood glucose and lipid profiles [ 12 , 13 , 14 ]. However, to date, no studies have successfully reported the effects of dietary supplementation of Caulerpa racemosa on the markers of cardiometabolic syndrome.…”