Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling

Zhang, Minglei; Chen, Li; Liu, Yang; Chen, Ming‐Hui; Zhang, Shuang; Kong, Daliang

doi:10.3892/or.2020.7614

Cited by 17 publications

(10 citation statements)

References 46 publications

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“…These results are consistent with previous reports. Zhang reported that fucoidan inhibited osteosarcoma cell adhesion by suppression of the phosphorylation of FAK and paxillin ( Zhang et al, 2020 ). In addition, fucoidan suppressed mouse hepatocarcinoma Hca-F cells adhesion via downregulating L-selectin and upregulating protein levels of tissue inhibitor of metalloproteinases (TIMPs) ( Wang et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

Zhao

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Fucoidan has received increasing attention in anti-(lung) tumors. However, the effect of fucoidan on the gene changes of lung cancer cells (LCCs) has not been examined systematically. Herein, we investigate the effect of fucoidan on the phenotypes of LCCs and their gene expression by transcriptome sequencing analysis. The phenotypes of LCCs are significantly inhibited by fucoidan. Importantly, compared to LCCs, 1 mg/ml fucoidan has no effect on the phenotypes of normal cells. Further, 6,930 differentially expressed genes (DEGs) in the transcriptome of LCCs (3,501 up-regulated and 3,429 down-regulated genes) are detected via RNA-sequencing between the fucoidan and control groups. Gene Ontology analysis confirms that DEGs are reflected in DNA replication, cell-substrate junction, regulation of cell cycle phase transition, apoptosis, focal adhesion, cadherin binding, and cell adhesion molecule binding. Thus, our findings on the transcriptomic level highlight the therapeutic potential of fucoidan for lung cancer treatment.

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Section: Resultsmentioning

confidence: 99%

A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

Zhao

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Fucoidan from the sea cucumber Cucumaria frondosa has been reported to inhibit in vitro migration of human osteosarcoma U2OS cells by impairing dynamic cytoskeletal remodeling through the suppression of the phosphorylation of FAK and paxillin and activation of the Rac1/PAK1/LIMK1/cofilin signaling axis [ 50 ].…”

Section: Marine Compounds As Migrastaticsmentioning

confidence: 99%

Marine Migrastatics: A Comprehensive 2022 Update

2022

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Metastasis is responsible for the bad prognosis in cancer patients. Advances in research on metastasis prevention focus attention on the molecular mechanisms underlying cancer cell motility and invasion to improve therapies for long-term survival in cancer patients. The so-called “migrastatics” could help block cancer cell invasion and lead to the rapid development of antimetastatic therapies, improving conventional cancer therapies. In the relentless search for migrastatics, the marine environment represents an important source of natural compounds due to its enormous biodiversity. Thus, this review is a selection of scientific research that has pointed out in a broad spectrum of in vitro and in vivo models the anti-cancer power of marine-derived products against cancer cell migration and invasion over the past five years. Overall, this review might provide a useful up-to-date guide about marine-derived compounds with potential interest for pharmaceutical and scientific research on antimetastatic drug endpoints.

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“…Yoshizawa and Coll demonstrated that 6-Hydroxythiobinupharidine isolated from Nuphar pumilum inhibits migration of LM8 OS cells by decreasing the expression of LIMK 1 [ 157 ]. More recently, Zhang and Coll showed that fucoidan from the sea cucumber Cucumaria frondosa inhibits OS adhesion and migration by regulating cytoskeleton remodelling via the Rac1/PAK1/LIMK1/cofilin signalling axis [ 158 ].…”

Section: Limks and Primary Bone Tumourmentioning

confidence: 99%

LIM Kinases in Osteosarcoma Development

Brion

Regnier

Mullard

et al. 2021

Cells

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Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades, bone cancers remain a leading cause of death worldwide among paediatric cancer patients. Osteosarcomas are the most common malignant bone tumours in children and adolescents. Notwithstanding advances in therapeutic treatments, many patients succumb to these diseases. In particular, less than 30% of patients who demonstrate metastases at diagnosis or are poor responders to chemotherapy survive 5 years after initial diagnosis. LIM kinases (LIMKs), comprising LIMK1 and LIMK2, are common downstream effectors of several signalization pathways, and function as a signalling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. In recent decades, several reports have indicated that the functions of LIMKs are mainly implicated in the regulation of actin microfilament and the control of microtubule dynamics. Previous studies have thus identified LIMKs as cancer-promoting regulators in multiple organ cancers, such as breast cancer or prostate cancer. This review updates the current understanding of LIMK involvement in osteosarcoma progression.

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Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling

Cited by 17 publications

References 46 publications

A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

Marine Migrastatics: A Comprehensive 2022 Update

LIM Kinases in Osteosarcoma Development

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