Sea anemone MACPF proteins demonstrate an evolutionary transitional state between venomous and developmental functions
Joachim M. Surm,
Morani Landau,
Yaara Y. Columbus-Shenkar
et al.
Abstract:Gene duplication is a major force driving evolutionary innovation. A classic example is generating new animal toxins via duplication of physiological protein-encoding genes and recruitment into venom. While this process drives the innovation of many animal venoms, reverse-recruitment of toxins into non-venomous cells remains unresolved. Using comparative genomics, we find members of the Membrane Attack Complex and Perforin Family (MACPF) have been recruited into venom-injecting cells (cnidocytes), in soft and … Show more
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