Se site targeted-two circles antioxidant in GPx4–like catalytic peroxide degradation by polyphenols (−)-epigallocatechin gallate and genistein using SERS

Zhang, Mengmeng; Liu, Jingbo; Gao, Yu; Zhao, Bing; Xu, Meng-Lei; Zhang, Ting

doi:10.1016/j.fochx.2024.101387

Cited by 1 publication

(2 citation statements)

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“… The synergistic action of these antioxidant enzymes maintains the balance of iron ions inside and outside the cell and reduces the occurrence of ferroptosis. On the contrary, enzymes like NADPH oxidase (NOX), xanthine oxidase (XO), lipoxygenase (LOX), cyclooxygenase (COX), and inducible nitric oxide synthase (iNOS) promote ROS production. , Curcumin and EGCG activate antioxidant enzymes such as SOD, CAT, and GSH-Px, leading to ROS detoxification. , Meanwhile, through catalysis of antioxidant enzymes such as GPx4 and NADPH, EGCG and genistein exert their antioxidant effects in a continuous cycle, effectively degrading peroxides and helping to maintain the redox balance of cells …”

Section: Fpps Classification and Antioxidant Propertiesmentioning

confidence: 99%

“…115,116 Meanwhile, through catalysis of antioxidant enzymes such as GPx4 and NADPH, EGCG and genistein exert their antioxidant effects in a continuous cycle, effectively degrading peroxides and helping to maintain the redox balance of cells. 117 Vitis vinifera red grape seed and skin extract (GSSE) (500 and 1000 μg/mL) exhibited in vitro and in vivo neuroprotective activity in a PD mouse model. GSSE protected dopamine neurons from neurotoxin 6-hydroxydopamine (6-OHDA) damage, reducing apoptosis, ROS production, and inflammatory markers.…”

Section: Fpps Classification and Antioxidant Propertiesmentioning

confidence: 99%

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Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang,

Liu,

et al. 2024

J. Agric. Food Chem.

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Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function and potentially triggering apoptosis or necrosis. This process is closely correlated with the onset of many diseases. Evidence suggests that the phenolic hydroxyl groups in food-borne plant polyphenols (FPPs) make them effective antioxidants capable of preventing diseases triggered by cell membrane LP. Proper dietary intake of FPPs can attenuate cellular oxidative stress, especially damage to cell membrane phospholipids, by activating the Nrf2/GPx4 pathway. Nuclear factor E2-related factor 2 (Nrf2) is an oxidative stress antagonist. The signaling pathway regulated by Nrf2 is a defense transduction pathway of the organism against external stimuli such as reactive oxygen species and exogenous chemicals. Glutathione peroxidase 4 (GPx4), under the regulation of Nrf2, is the only enzyme that reduces cell membrane lipid peroxides with specificity, thus playing a pivotal role in regulating cellular ferroptosis and counteracting oxidative stress. This study explored the Nrf2/GPx4 pathway mechanism, antioxidant activity of FPPs, and mechanism of LP. It also highlighted the bioprotective properties of FPPs against LP and its associated mechanisms, including (i) activation of the Nrf2/GPx4 pathway, with GPx4 potentially serving as a central target protein, (ii) regulation of antioxidant enzyme activities, leading to a reduction in the production of ROS and other peroxides, and (iii) antioxidant effects on LP and downstream phospholipid structure. In conclusion, FPPs play a crucial role as natural antioxidants in preventing LP. However, further in-depth analysis of FPPs coregulation of multiple signaling pathways is required, and the combined effects of these mechanisms need further evaluation in experimental models. Human trials could provide valuable insights into new directions for research and application.

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