SDMA as a marker and mediator in cerebrovascular disease
Alexandra Riddell,
Arun Flynn,
Hugo Bergugnat
et al.
Abstract:Symmetric dimethylarginine (SDMA) is a methylated derivative of arginine, generated by all cells as a by-product of cellular metabolism and eliminated via the kidney. For many years SDMA has been considered inert and of little biological significance. However, a growing body of evidence now suggests this view is outdated and that circulating SDMA levels may, in fact, be intricately linked to endothelial dysfunction and vascular risk. In this review, we specifically examine SDMA within the context of cerebrovas… Show more
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