SDHB reduces chemotherapy resistance in ovarian cancer cells by affecting epithelial mesenchymal transition through DNA damage repair
Lilan Chen,
Wen Di
Abstract:Background: Ovarian carcinoma is one of the most common gynecological cancers with high mortality rates. Succinate dehydrogenase (SDH or Complex II) which is one of the important enzymes in the tricarboxylic acid (TCA) cycle plays an important role in carcinomas. Succinate dehydrogenase subunit B (SDHB) gene, which encodes one of the four subunits of SDH, has been found played as a tumor suppressor role in ovarian cancer. However, the role of SDHB in ovarian cancer chemotherapy is still unclear.
Methods: Using… Show more
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