SDF-1α as a therapeutic stem cell homing factor in myocardial infarction

Ghadge, Santhosh Kumar; Mühlstedt, Silke; Özcelik, C.; Bäder, Michael

doi:10.1016/j.pharmthera.2010.09.011

Cited by 195 publications

(178 citation statements)

References 142 publications

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“…These studies confirmed that cardiac function is improved by increasing stem cell homing, angiogenesis, and anti-fibrosis. [7][8][9][10][11] Recently, the effects of substance P (SP) on wound-healing processes have been reported in several articles. SP is an 11-amino-acid neuropeptide secreted from the peripheral terminals of sensory nerve fibers.…”

mentioning

confidence: 99%

Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

Kim

Hur

Kim

et al. 2015

Tissue Engineering Part A

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mentioning

confidence: 99%

Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

Kim

Hur

Kim

et al. 2015

Tissue Engineering Part A

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“…5,6 Various cytokines are essential for homing, proliferation, and differentiation of stem/progenitor cells in the process of tissue regeneration. 7,8 Cytokines have been widely studied in tissue regeneration, but their short half-lives and the low local concentrations render their application limited. 9,10 Therefore, a reliable delivery system able to localize cytokines to specific tissues for an extended period of time and maintain their bioactivity could improve the homing, differentiation, and proliferation of stem/progenitor cells at their target tissue.…”

mentioning

confidence: 99%

Novel stable cytokine delivery system in physiological pH solution: chitosan oligosaccharide/heparin nanoparticles

Wang

Tan

Deng

et al. 2015

IJN

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Background Cell therapy is a promising strategy for tissue regeneration. Key to this strategy is mobilization and recruitment of exogenous or autologous stem/progenitor cells by cytokines. However, there is no effective cytokine delivery system available for clinic application, in particular for myocardial regeneration. The aim of this study was to develop a novel cytokine delivery system that is stable in solution at physiological pH. Methods Four groups of self-assembled chitosan oligosaccharide/heparin (CSO/H) nanoparticles were prepared with various volume ratios of chitosan oligosaccharide to heparin (5:2, 5:4, 4:15, 1:5) and characterized by laser diffraction, particle size analysis, and transmission electron microscopy. The encapsulation efficiency and loading content of two cytokines, ie, stromal cell-derived factor (SDF)-1α and vascular endothelial growth factor (VEGF) were quantified using an enzyme-linked immunosorbent assay. The biological activity of the loaded SDF-1α and VEGF was evaluated using the transwell migration assay and MTT assay. The dispersion profiles for the cytokine-loaded nanoparticles were quantified using fluorescence molecular tomography. Results CSO/H nanoparticles were prepared successfully in solution with physiological pH. The particle sizes in the four treatment groups were in the range of 96.2–210.5 nm and the zeta potential ranged from −29.4 mV to 24.2 mV. The loading efficiency in the CSO/H nanoparticle groups with the first three ratios was more than 90%. SDF-1α loaded into CSO/H nanoparticles retained its migration activity and VEGF loaded into CSO/H nanoparticles continued to show proliferation activity. The in vivo dispersion test showed that the CSO/H nanoparticles enabled to VEGF to accumulate locally for a longer period of time. Conclusion CSO/H nanoparticles have a high cytokine loading capacity and allow cytokines to maintain their bioactivity for longer, are stable in an environment with physiological pH, and may be a promising cytokine delivery system for tissue regeneration.

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“…This small fraction may not reflect the overall cell distribution. Under the studied conditions, the anterograde route seems to have advantage over the retrograde one, but more studies are still needed, with the introduction of new parameters, such as, cell selection and association of growth factors 21,22 .…”

Section: Moreira Et Al Stem-cell Injection After Amimentioning

confidence: 99%

Injeção intracoronariana de células tronco após infarto do miocárdio: subestudo da microcirculação

Moreira¹,

Haddad²,

Silva³

et al. 2011

Arq. Bras. Cardiol.

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SDF-1α as a therapeutic stem cell homing factor in myocardial infarction

Cited by 195 publications

References 142 publications

Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

Novel stable cytokine delivery system in physiological pH solution: chitosan oligosaccharide/heparin nanoparticles

Injeção intracoronariana de células tronco após infarto do miocárdio: subestudo da microcirculação

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SDF-1α as a therapeutic stem cell homing factor in myocardial infarction

Cited by 195 publications

References 142 publications

Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

Novel stable cytokine delivery system&nbsp;in physiological pH solution: chitosan oligosaccharide/heparin nanoparticles

Injeção intracoronariana de células tronco após infarto do miocárdio: subestudo da microcirculação

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Novel stable cytokine delivery system in physiological pH solution: chitosan oligosaccharide/heparin nanoparticles