SDEvelo: a deep generative approach for transcriptional dynamics with cell-specific latent time and multivariate stochastic modeling
Jin Liu,
Xu Liao,
Hongkai Ji
et al.
Abstract:Recently, RNA velocity has driven a paradigmatic change in single-cell RNA sequencing (scRNA-seq) studies, allowing the reconstruction and prediction of directed trajectories in cell differentiation and state transitions. However, most existing methods use dynamic modeling via ordinary differential equations (ODE) for individual genes in sequence and can lead to erroneous results, as they are inadequately able to fully capture the intrinsically stochastic nature of transcriptional dynamics governed by a cell-s… Show more
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