Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction

Shahmohammadi, Alireza; Golchoobian, Ravieh; Mirahmadi, Seyed-Mohamad-Sadegh; Rousta, Ali Mohammad; Ansari, Fariba; Sharayeli, Maryam; Baluchnejadmojarad, Tourandokht; Roghani, Mehrdad

doi:10.1080/08923973.2022.2141644

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…Yang et al found that langoustine exerts a protective effect against AKI through anti-inflammation and antioxidant activity [ 88 ]. Shahmohammadi et al found that scutellarin can inhibit acute renal injury induced by regulating Nrf2/PPAR-c/PGC-1a/NF-kB/TLR4 [ 89 ].…”

Section: Pharmacological Effectsmentioning

confidence: 99%

Current advances on the therapeutic potential of scutellarin: an updated review

Xie,

Sun,

Tao

et al. 2024

Nat. Prod. Bioprospect.

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Scutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteraceae, and belongs to flavonoids. Scutellarin has a wide range of pharmacological activities, it is widely used in the treatment of cerebral infarction, angina pectoris, cerebral thrombosis, coronary heart disease, and other diseases. It is a natural product with great research and development prospects. In recent years, with in-depth research, researchers have found that wild scutellarin also has good therapeutic effects in anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, treatment of metabolic diseases, and protection of kidney. The cancer treatment involves glioma, breast cancer, lung cancer, renal cancer, colon cancer, and so on. In this paper, the sources, pharmacological effects, in vivo and in vitro models of scutellarin were summarized in recent years, and the current research status and future direction of scutellarin were analyzed. Graphical Abstract

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Section: Pharmacological Effectsmentioning

confidence: 99%

Current advances on the therapeutic potential of scutellarin: an updated review

Xie,

Sun,

Tao

et al. 2024

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

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Identification of Xuanfei Baidu granule constituents by liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry and its anti‐inflammatory active constituents using a lipopolysaccharide‐induced RAW264.7 cell model

Li,

Zhao,

Liang

et al. 2024

Biomedical Chromatography

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The Xuanfei Baidu (XFBD) prescription, a traditional Chinese medicine prescription, has demonstrated significant anti‐inflammatory activities; however, the number of its reported constituents is limited, and its anti‐inflammatory constituents are unclear. In this study, the constituents of XFBD granule, a granule dosage of XFBD prescription, were thoroughly examined in vitro and in vivo using liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry, and the anti‐inflammatory constituents were screened. A total of 214 constituents were identified from the XFBD granule, 62 of which were confirmed via comparison with reference standards. After intragastric administration of XFBD granule, 63 and 28 constituents were absorbed into the rat sera and lungs in prototype form, respectively. XFBD granule and XFBD‐containing serum were found to significantly reduce nitric oxide (NO) and interleukin‐6 (IL‐6) secretion in lipopolysaccharide‐induced RAW264.7 cells. Five anti‐inflammatory constituents (verbasoside, scutellarin, luteolin, apigenin, and pogostone) were found to reduce the concentration of NO and IL‐6 in a dose‐dependent manner. Moreover, the combination of these five constituents could significantly reduce NO secretion even when the concentration of each constituent was two to three orders of magnitude lower than their individual minimum effective concentrations. Overall, this study provides a valuable reference for the discovery of effective constituents from the XFBD granule.

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The role of mitochondrial quality surveillance in skin aging: Focus on mitochondrial dynamics, biogenesis and mitophagy

Zhang

Gao

et al. 2023

Ageing Research Reviews

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Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction

Cited by 4 publications

References 46 publications

Current advances on the therapeutic potential of scutellarin: an updated review

Current advances on the therapeutic potential of scutellarin: an updated review

Identification of Xuanfei Baidu granule constituents by liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry and its anti‐inflammatory active constituents using a lipopolysaccharide‐induced RAW264.7 cell model

The role of mitochondrial quality surveillance in skin aging: Focus on mitochondrial dynamics, biogenesis and mitophagy

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