Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression
Zhao Cui,
Caifeng Li,
Wei Liu
et al.
Abstract:Isochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and is considered to have potential antitumor effects. The activation of IDH1 as a pathway for the development of anticancer drugs has not been attempted. We demonstrated that IDH1 can limit glycolysis in hepatocellular carcinoma (HCC) cells to activate the tumor immune microenvironment. In addition, through proteomic microarray analysis, we identified a natural small mo… Show more
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