Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF‐kappaB signaling pathway: In vitro and in vivo studies
Ziyang Ye,
Zhihan Ge,
Shu Yang
et al.
Abstract:Osteoarthritis (OA), a joint disease that is associated with inflammatory processes is involved in joint destruction. Scutellarein (Scu), a component of the medicinal herbs Scutellaria barbata D. Don and Erigeron breviscapus (vant) Hand Mass, has anti‐inflammatory effects. We explored the role of Scu in the development of OA and the underlying mechanisms. CCK‐8 assays, Calcein‐AM/PI and EdU staining were used to determine chondrocyte viability after Scu exposure. Western blot, qPCR, as well as ELISA were utili… Show more
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