SCUBE2, vascular endothelium, and vascular complications: A systematic review

Ali, Hirowati

doi:10.1016/j.biopha.2020.110129

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…SCUBE2, as a member of the SCUBE family, is expressed in a wide range of human tissues including cardiovascular tissues. SCUBE2 is involved in vascular endothelial function changes and vascular complications, particularly in diabetes and atherosclerosis ( 45 ). The results of our study suggested that SCUBE2 might be a new target that played an important role in ICM.…”

Section: Discussionmentioning

confidence: 99%

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

Wang

Xie

Cheng

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveInflammation plays an important role in the pathophysiology of ischemic cardiomyopathy (ICM). We aimed to identify potential biomarkers of inflammation-related genes for ICM and build a model based on the potential biomarkers for the diagnosis of ICM.Materials and methodsThe microarray datasets and RNA-Sequencing datasets of human ICM were downloaded from the Gene Expression Omnibus database. We integrated 8 microarray datasets via the SVA package to screen the differentially expressed genes (DEGs) between ICM and non-failing control samples, then the differentially expressed inflammation-related genes (DEIRGs) were identified. The least absolute shrinkage and selection operator, support vector machine recursive feature elimination, and random forest were utilized to screen the potential diagnostic biomarkers from the DEIRGs. The potential biomarkers were validated in the RNA-Sequencing datasets and the functional experiment of the ICM rat, respectively. A nomogram was established based on the potential biomarkers and evaluated via the area under the receiver operating characteristic curve (AUC), calibration curve, decision curve analysis (DCA), and Clinical impact curve (CIC).Results64 DEGs and 19 DEIRGs were identified, respectively. 5 potential biomarkers (SERPINA3, FCN3, PTN, CD163, and SCUBE2) were ultimately selected. The validation results showed that each of these five potential biomarkers showed good discriminant power for ICM, and their expression trends were consistent with the bioinformatics results. The results of AUC, calibration curve, DCA, and CIC showed that the nomogram demonstrated good performance, calibration, and clinical utility.ConclusionSERPINA3, FCN3, PTN, CD163, and SCUBE2 were identified as potential biomarkers associated with the inflammatory response to ICM. The proposed nomogram could potentially provide clinicians with a helpful tool to the diagnosis and treatment of ICM from an inflammatory perspective.

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Section: Discussionmentioning

confidence: 99%

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

Wang

Xie

Cheng

et al. 2022

Front. Cardiovasc. Med.

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“…Recent advances in this area have also highlighted a shared mechanistic pathway involving inflammation and endothelium oxidation in endothelial dysfunction (212,213) . For instance, SNPs involved in processes related to endothelial and vascular health such as vascular endothelial growth factor receptor, platelet/endothelial cell adhesion molecule-, endothelial nitric oxide synthase and endothelin-1 contribute to local and systemic vascular disorders (214)(215)(216)(217)(218) , yet studies had small sample sizes, were limited in number or did not account for gene-environment interaction.…”

Section: The Link Between Risk Factors and Endothelial Dysfunction An Intermediary Marker Of Cvdmentioning

confidence: 99%

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

Vale¹,

Buckner²,

Mitrofan³

et al. 2021

Nutr. Res. Rev.

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Cardiovascular disease (CVD) is the most common non-communicable disease occurring globally. Although previous literature have provided useful insights on the important role that diet play in CVD prevention and treatment, understanding the causal role of diets is a difficult task considering inherent and introduced weaknesses of observational (e.g., not properly addressing confounders and mediators) and experimental research designs (e.g., not appropriate or well-designed). In this narrative review, we organised current evidence linking diet, as well as conventional and emerging physiological risk factors with CVD risk, incidence and mortality in a series of diagrams. The diagrams presented can aid causal inference studies as they provide a visual representation of the types of studies underlying the associations between potential risk markers/factors for CVD. This may facilitate the selection of variables to be considered and the creation of analytical models. Evidence depicted in the diagrams was systematically collected from studies included in the British Nutrition Task Force report on Diet and CVD and database searches, including Medline and Embase. Although several markers and disorders linked to conventional and emerging risk factors for CVD were identified, the causal link between many remains unknown. There is a need to address the multifactorial nature of CVD and the complex interplay between conventional and emerging risk factors with natural and built environments, while bringing the life course and the role of additional environmental factors into the spotlight.

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“…Поддержание микроциркуляции на достаточном уровне обеспечивается благодаря ингибированию адгезии и агрегации тромбоцитов, ограничению активации коагуляционных механизмов в каскадах взаимодействий тромбомодулин / протеин С, гепарин / антитромбин и плазминоген / плазмин и регуляции фибринолиза за счет синтеза t-PA и PAI-1 [39] Многочисленные патологические процессы, такие как атеросклероз, воспаление, кардиомиопатия, гипертония и т. д., сопровождаются формированием ЭДФ [16]. Окислительный стресс, воспаление, деградация и пролиферация гликокаликса при метаболических нарушениях являются факторами, которые ускоряют развитие ЭДФ [5]. Механизмы формирования ЭДФ, особенно при ПОУГ, начинаются с повреждения межклеточных контактов эндотелиоцитов и структуры гематоофтальмического барьера, что приводит к усилению адгезии лейкоцитов с экстравазацией, индукции прокоагулянтов и антифибринолитических систем [16].…”

Section: факторы развития и патогенез первичной открытоугольной глаукомыunclassified

Распространенность И Эпидемиология Первичной Открытоугольной Глаукомы

Isaev¹,

Сердюк²,

Устименко³

2021

Офтальмология. Восточная Европа

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Глаукома рассматривается как гетерогенная группа заболеваний со специфическим изменением биомеханики передней и задней камер глаза, результатом чего является увеличение продукции и уменьшение оттока водянистой влаги. Прогрессирующая дегенерация ганглиозных клеток сетчатки, микроглии, астроцитов, клеток Мюллера приводит к хроническому повреждению, истончению нейроретинального слоя и сужению поля зрения. Предметом данного исследования стала первичная по происхождению глаукома с открытым углом (ПОУГ). Именно ПОУГ, по данным многих исследований Американской оптометрической ассоциации, является наиболее распространенным видом глаукомы (72-96%), особенностью которой выступает беcсимптомность развития с постепенным снижением периферического зрения. Причиной такого патологического состояния являются повреждение зрительного нерва, неэффективность дренажной системы глаза с накоплением жидкости и повышением ВГД. Проблема изучения развития и прогрессирования ПОУГ из года в год становится все более актуальной. Анализ эпидемиологических исследований за последние полвека показал, что заболеваемость глаукомой демонстрирует стремительный рост. Данная статья представляет собой обзор литературы с точки зрения выделения ряда геновкандидатов. Значительный научный интерес представляет полиморфизм гена NOS3 через его влияние на формирование эндотелиальной дисфункции. Определение связи полиморфизмов rs1799983 и rs2070744 с развитием и прогрессированием ПОУГ. Поиск литературы выполнялся по таким базам научной литературы, как Web of Science, Google Scholar, PubMed, Scopus и другие. Генетическая детерминированность возникновения и прогрессирования ПОУГ позволяет выделить ряд генов-кандидатов. Значительный научный интерес представляет полиморфизм гена NOS3 из-за его влияния на формирование эндотелиальной дисфункции. Определение связи полиморфизмов rs1799983 и rs2070744 с развитием и прогрессированием ПОУГ, клиническими проявлениями заболевания позволит усовершенствовать ее раннюю диагностику и профилактику осложнений. Glaucoma is considered as a heterogeneous group of diseases with a specific change in biomechanics of the anterior and posterior chambers of the eye, resulting in a production increase and a decrease in aqueous humor outflow. Progressive degeneration of retinal ganglion cells, microglia, astrocytes, Mueller cells, leads to chronic damage, thinning of the neuroretinal layer and narrowing of visual field. The subject of this study is a primary in origin open-angle glaucoma (POAG). According to many studies by the American Optometric Association, POAG is the most common type of glaucoma (72-96%), characterized by asymptomatic development with a gradual decrease in peripheral vision. The reason for this pathological condition is damage of optic nerve, inefficiency of eye drainage system with fluid accumulation and increased intraocular pressure. The problem of POAG development and progression study becomes more and more relevant each year. In terms of epidemiological studies for the past 50 years, the incidence of glaucoma morbidity shows a rapid progressive increase. Review of the literature in terms of identifying a number of candidate genes. The polymorphism of the NOS3 gene through its influence on the formation of endothelial dysfunction is of considerable scientific interest. Determination of the relationship of the rs1799983 and rs2070744 polymorphisms with the development and progression of POAG. This article is а literature rewiev was performed in following database of scientific literature: Web of Science, Google Scholar, PubMed, Scopus and others. The genetic determinism of the occurrence and progression of POAG makes it possible to identify a number of candidate genes. The polymorphism of the NOS3 gene is of considerable scientific interest due to its influence on the formation of endothelial dysfunction. Determination of the relationship between the rs1799983 and rs2070744 polymorphisms with the development and progression of POAG, clinical manifestations of the disease will improve its early diagnosis and prevention of complications.

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SCUBE2, vascular endothelium, and vascular complications: A systematic review

Cited by 11 publications

References 37 publications

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

Распространенность И Эпидемиология Первичной Открытоугольной Глаукомы

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