scStateDynamics: deciphering the drug-responsive tumor cell state dynamics by modeling single-cell level expression changes
Jin Gu,
Wenbo Guo,
Xinqi Li
et al.
Abstract:Understanding the heterogeneity and dynamic plasticity of tumor cells is crucial for overcoming drug resistance. Single-cell technologies enable the analysis of cell states at a given condition or time point, but it is still challenging to catenate static tumor cell snapshots to characterize their dynamic responses after drug treatment. Here, we propose scStateDynamics, an algorithm to infer tumor cell state dynamics and identify common drug effects by modeling single-cell level gene expression changes. We fir… Show more
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