scSemiProfiler: Advancing large-scale single-cell studies through semi-profiling with deep generative models and active learning
Jingtao Wang,
Gregory J. Fonseca,
Jun Ding
Abstract:Single-cell sequencing is a crucial tool for dissecting the cellular intricacies of complex diseases. Its prohibitive cost, however, hampers its application in expansive biomedical studies. Traditional cellular deconvolution approaches can infer cell type proportions from more affordable bulk sequencing data, yet they fall short in providing the detailed resolution required for single-cell-level analyses. To overcome this challenge, we introduce “scSemiProfiler”, an innovative computational framework that marr… Show more
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