Scrutinizing the stability of haemoglobin in 1,2,4-triazolium based ionic liquid

Singh, Dharmendra; Panigrahi, Suraj Kumar; Sharma, Gyanendra; Gardas, Ramesh L.

doi:10.1016/j.molliq.2021.118213

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…An overview of the protein-related inhibitory potentials of various ILs is given in Table . There are also studies on IL effects on crucial proteins such as myoglobin (see, e.g., refs − ), hemoglobin (see, e.g., , − ), cytochrome c (see, e.g., − ), and serum albumins (see, e.g., , − ), but we intentionally leave them beyond the scope of our consideration due to significant difficulties in relating the observed stabilizing/destabilizing effects to the toxic impact of a given IL on the whole organism.…”

Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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“…[17] Further, Singh et al have used an IL as a co-solvent to estimate the interaction between Hb and triazolium-based IL. [18] They have reported that Hb is structurally stable at lower concentrations of triazolium-based ILs, whereas denaturation occurs at higher concentrations. Hb is found to be structurally stable and unstable depending on the IL.…”

Section: Introductionmentioning

confidence: 99%

Effect of Choline Amino Acid‐Based Ionic Liquids on Stability and Structure of Hemoglobin

Devi Tulsiyan,

Rani Prusty,

Biswal

2023

ChemPhysChem

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Ionic liquids (ILs) can stabilize or destabilize proteins, which motivates us to examine their effect on hemoglobin. The native state of hemoglobin (Hb) is disrupted at different physical conditions such as pressure, temperature, and solvents. Herein, we have monitored the stability of Hb in a nontoxic and biocompatible IL, i. e., choline amino acid‐based Ils (ChAAILs), using various spectroscopic techniques like UV‐Vis and fluorescence spectroscopy, circular dichroism (CD), and isothermal titration calorimetry (ITC) measurements. It was observed that Hb stays neither in its native state nor in its fully denatured state; rather, it achieves an intermediate state in the presence of ChAAILs. The research on the intermediate state of Hb is still unexplored. Research has been pursued to find a suitable ligand or IL that can stabilize the intermediate state of Hb. In that context, ChAAILs are among the best choices. Molecular docking studies unravel the binding of ChAAILs with Hb. The obtained binding energies of the docked complex are −7.2 kcal/mol and −8.7 kcal/mol for binding of Hb with [Chl][Gly] and [Chl][Met], respectively, which was in line with the ITC results. The quantum chemical calculations show that H‐bond plays a significant role for the interaction between Hb and ChAAILs.

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A review of ionic liquids: Recent synthetic advances and oilfield applications

Hussain,

Adewunmi,

Alade

et al. 2023

Journal of the Taiwan Institute of Chemical Engineers

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Scrutinizing the stability of haemoglobin in 1,2,4-triazolium based ionic liquid

Cited by 9 publications

References 47 publications

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Effect of Choline Amino Acid‐Based Ionic Liquids on Stability and Structure of Hemoglobin

A review of ionic liquids: Recent synthetic advances and oilfield applications

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