Scrub typhus : A literature review

Baranwal, Arun; Subramani, S Vignesh

doi:10.21304/2019.0604.00515

Cited by 2 publications

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“…Vascular injury to capillary endothelium may be the causative factor for capillary leak. 14 Edema has been reported from 37% to 60% in two studies from India. 8,13 Our study reported edema in 77% of the patients.…”

Section: Discussionmentioning

confidence: 98%

Clinical and laboratory profile of Scrub typhus in paediatric age group

Mishra

Thakur

2020

Asian J Med Sci

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Background: Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi, obligate intracellular organism. Incidence of Scrub typhus is increasing due to easy availability and decreased cost of diagnostic facility. This study was designed to study the clinical and laboratory profile of scrub typhus patient in department of paediatrics at National Medical College, Birgunj. Aims and Objectives: To study the clinical manifestations, laboratory findings and complications of Scrub typhus in Pediatric age group. Methods and Methods: A prospective observational study was carried out in children below the age of 15 years, admitted in paediatrics department of a tertiary care hospital of Nepal from June 2019 to May 2020. Clinical manifestations and laboratory findings were collected and recorded in predesigned data sheet. Scrub typhus was diagnosed with IgM ELISA. Results: A total of 52 patients were diagnosed as scrub typhus. All patients presented with fever and commonly had other symptoms such as headache (65.3%), vomiting (63.5%), cough (59.6%), breathing difficulty (57.7%), abdominal pain (53.9%), seizures (21.2%) and rashes (9.6%). Important clinical signs noticed were lymphadenopathy (84.6%), edema (76.4%), hepatomegaly (56.8%), splenomegaly (36.5%) jaundice (30.7%). About 12% (n = 9) had necrotic eschar. 54% of the admitted patient confirmed using open defecation. Myocarditis (67.3%) was the commonest complication followed by Acute Kidney Injury (65.4%). Conclusions: Scrub typhus must be considered in differential of tropical fever in children, especially in those residing in rural area and having open defecation. In our study, Fever was the ubiquitous symptom and Myocarditis was the commonest complication.

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Section: Discussionmentioning

confidence: 98%

Clinical and laboratory profile of Scrub typhus in paediatric age group

Mishra

Thakur

2020

Asian J Med Sci

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“…2 Clinical spectrum of disease varies from mild febrile illness to multi organ dysfunction such as hepatic derangement, acute renal failure, pneumonitis with acute respiratory distress syndrome (ARDS), myocarditis, septic shock, meningoencephalitis, and disseminated intravascular coagulation (DIC) are well-documented. [3][4][5] Widespread damage of endothelial cells leads to release of pro-inflammatory cytokines followed by leucocytes recruitment and chemokine release, 6 ultimately resulting in multi-organ damage.…”

Section: Introductionmentioning

confidence: 99%

Clinico-demographic and hepatic profile as outcome predictor in scrub typhus in pediatric age group

et al. 2023

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Background: Scrub Typhus, a Rickettsial disease is an emerging tropical disease mainly in South East Asia. Very few studies are there in pediatric age group and mainly limited to epidemiological and clinical profile only. Aims and Objectives: The main objective of this study is to assess different clinical, laboratory, and biochemical parameters denoting hepatic function in scrub typhus and their role in measuring final outcome and disease severity. Materials and Methods: This observational study included 90 children with history of febrile illness for ≥5 days between 1 and 12 years of age, diagnosed to be a case of scrub typhus by positive IgM ELISA test to assess the hepatic involvement by different clinical, laboratory, and radiological parameters and also to find out their role in disease severity and outcome. Results: Fever followed by vomiting was the most common symptoms with eschar evident in only three patients. Raised aspartate transaminase (AST) and alanine transaminase (ALT) were seen in 71.1% and 64.4%, respectively, with hypoalbuminemia in 78.9%, hepatomegaly in 47.8%, and only 2.2% had altered hepatic echotexture on ultrasonography. All of them had ALT: lactate dehydrogenase (LDH) ratio of <5. Shock was the most important predictor of duration of hospital stay whereas serum AST was an important predictor for final outcome and duration of hospital stay. Conclusion: Predominant feature of hepatic involvement in scrub typhus resembles that of anicteric hepatitis. Serum ALT: LDH ratio may be an important indicator of scrub hepatitis. Among lab parameters serum AST is the most important predictor of disease mortality and morbidity.

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Scrub typhus : A literature review

Cited by 2 publications

References 0 publications

Clinical and laboratory profile of Scrub typhus in paediatric age group

Clinical and laboratory profile of Scrub typhus in paediatric age group

Clinico-demographic and hepatic profile as outcome predictor in scrub typhus in pediatric age group

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