Scrotal wall metastasis as the first manifestation of primary gastric adenocarcinoma

A rare case of anal squamous cell carcinoma metastasizing to the scrotum

“…Metastases to the scrotum are uncommon. 3 Anal carcinoma metastasizing to the scrotum is a rare phenomenon that was observed in our patient. Metastatic spread could be included in the differential diagnosis for atypical scrotal lesions if the history is suggestive, and examination of the scrotum could be considered for patients with anal cancer because the lower anal canal and scrotum both drain to superficial inguinal lymph nodes.…”

“… 5 Cancers that have been observed to metastasize to the scrotum include colorectal cancer, prostate cancer, lung cancer, and gastric adenocarcinoma. 3 , 6 …”

Scrotal wall metastasis from a primary lung adenocarcinoma

“…A review of the literature could only identify sporadic cases of paratesticular metastasis, the primaries being from malignant melanoma, anal carcinoma, renal cell carcinoma [7] , transitional cell carcinoma [8,9] , gastric and colorectal carcinoma [10–12] , desmoplastic small cell tumor [13] , signet ring cell carcinoma [14] , adenocarcinoma of prostate [15] . Among those we found only four cases of primary lung carcinoma: two presented as painful scrotal wall thickening (carcinoma en Cuirasse) [16,17] , the third one was described as a left scrotal mass in the inner layers of the scrotal wall, separate from the left testicle, epididymis and spermatic cord [18] , the fourth case was a metastatic scrotal tumor from a lung adenocarcinoma with a micropapillary component [19] .…”