Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes

Zikry, Joseph; Chapman, Lance W.; Korta, Dorota Z.; Smith, Janellen

doi:10.1097/dss.0000000000001072

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Scrotal melanomas are associated with high mortality and late presentation. Zikry et al 1 conducted a systematic literature review, yielding 23 cases with scrotal melanoma and found that tumor presented as stage I/II disease 18.75% of the time, stage III 56.3% of the time, and stage IV 25% of the time, whereas typical cutaneous melanoma presents as stage I/II disease 84% of the time. They also reported that half of patients experienced recurrence of their disease.…”

Section: Discussionmentioning

confidence: 99%

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Primary scrotal melanoma: it is time to destigmatize genital lesions

Özkur

Altunay

2019

Anais Brasileiros de Dermatologia

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Primary male genital melanomas are very rare; they are associated with high mortality and late detection. Scrotal melanoma is the least common presentation and only 23 cases have been reported. Herein, the authors present a 30-year-old patient with stage IIIC (T4b, N2a, M0) scrotal melanoma in order to report the characteristics, treatment, and outcome, as well as to emphasize the importance of examination of the genitals, education of patients about self-examination and destigmatizing genital lesions to increase the likelihood of earlier detection.

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Section: Discussionmentioning

confidence: 99%

“…Primary male genital melanomas are very rare; among them, scrotal melanoma is the least common, and only 23 cases have been reported so far in medical literature 1 . Genitourinary (GU) melanomas can arise from cutaneous ( i.e ., scrotum, penile shaft) or mucosal (urothelial) surfaces.…”

Section: Introductionmentioning

confidence: 99%

Primary scrotal melanoma: it is time to destigmatize genital lesions

Özkur

Altunay

2019

Anais Brasileiros de Dermatologia

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“…Responses were received from 121 resident physicians (33.9% men, 66.1% women) (Table I), but the exact response rate could not be calculated because we did not know how many residents actually received a survey from their program Anogenital melanoma is uncommon but is classically associated with an aggressive disease course and poor prognosis. 3,4 The 5-year survival rate is 37.41% for genitourinary melanoma and 16.68% for anorectal melanoma. 5 This is likely related to the advanced stage at presentation, emphasizing the need for early detection.…”

Section: Anogenital Examination Practices Among United States Dermatology Residentsmentioning

confidence: 99%

“…False negatives lead to significant diagnostic and treatment delays. Additionally, biopsies may be associated with serious complications 3. To better characterize the role of skin biopsy with histopathologic evaluation in diagnosing calciphylaxis, this study investigatedTable I.…”

mentioning

confidence: 99%

Anogenital examination practices among United States dermatology residents

Hosking

Chapman

Zachary

et al. 2021

Journal of the American Academy of Dermatology

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relationship between the studied case report characteristics and number of citations. However, 3 characteristics trended toward being associated with a greater number of citations: inclusion of multiple patients (ie, case series), inclusion of before-after photographs, and discussion of new treatment modalities. Some findings trended against their expected outcome. For example, case reports with images averaged approximately 6 fewer citations than those without images, and case reports with dermatopathology averaged approximately 0.5 fewer citations than those without it. This may suggest that although the presence of clinical and dermatopathology images enhances article readability (at least in our opinion), it does not affect citations.Our findings suggest that no single case report characteristic can necessarily predict its influence. Additionally, case series and descriptions of new treatment modalities may be most likely to affect subsequent research endeavors as measured by citations. The number of citations may belie a case report's true influence. Ultimately, even as case reports are transitioned into case-report-only journals, they are essential in advancing the field of dermatology. Therefore, we encourage JAAD readers to share their findings in JAAD Case Reports to promote the advancement of our field.

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Dermatoses of the Male Genitalia

Bunker,

Watchorn

2024

Rook's Textbook of Dermatology

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Male genital dermatoses present a diverse array of symptoms including itch, pain, cracking, blistering, bruising, dysuria and dyspareunia, and can affect quality of life in terms of sexual, dermatological, psychological and urological morbidity. Dermatoses such as psoriasis, lichen planus and atopic eczema may manifest in specific morphology in the genital region, while other dermatoses such as lichen sclerosus, have a genital predilection, and subtle clinical signs that require assiduous assessment and a trained eye to detect. Treatment may present similar challenges due to the essential functions and associated stressors in the region. Precancerous pathologies also present challenges in terms of clinical recognition, and treatment, with diverse morphologies and region‐specific predisposing factors, and surgical challenges in terms of preserving sexual and urinary function.

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Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes

Abstract: Scrotal melanoma is rare, aggressive, and is often caught late in the disease course. The authors encourage dermatologists to educate patients and destigmatize genital lesions to increase the likelihood of earlier detection and better patient outcomes.

Cited by 5 publications

References 19 publications

Primary scrotal melanoma: it is time to destigmatize genital lesions

Primary scrotal melanoma: it is time to destigmatize genital lesions

Anogenital examination practices among United States dermatology residents

Dermatoses of the Male Genitalia

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