Scrotal Fibroepithelial Polyp With Acute and Chronic Inflammation Mimics Malignancy on 18F-FDG PET/CT Imaging

Chuang, Tzyy‐Ling; Tseng, Chih-En; Huang, Shih-Wen; Wang, Yuh-Feng

doi:10.1097/rlu.0000000000002771

Cited by 3 publications

(2 citation statements)

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“…In the pelvic region, activity retention within the urinary tract and 18 F-FDG uptake in the normal intestine over very short segments are common sources of false-positives ( 7 ). At the same, 18 F-FDG PET/CT lacks specificity in differentiating inflammation ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

68Ga-DOTA-FAPI-04 PET/CT as a Promising Tool for Differentiating Ovarian Physiological Uptake: Preliminary Experience of Comparative Analysis With 18F-FDG

et al. 2021

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Objectives: This study aimed to investigate the physiological distribution characteristics of 68Ga-DOTA-FAPI-04 in the ovary, and assess the feasibility of early diagnosis of primary ovarian disease with 68Ga-DOTA-FAPI-04 PET/CT.Methods: We retrospectively analyzed the data of patients who received 18F-FDG and 68Ga-DOTA-FAPI-04 PET/CT scanning in the Nuclear Medicine Department of our hospital within 3 days from September 2020 to January 2021. We selected the data in which ovaries showed abnormal FDG activity. Patients with abnormal ovarian FDG uptake with focus confirmed by pathological biopsy or clinical follow-up as pathological changes were excluded. The uptake of tracers (18F-FDG and 68Ga-FAPI) was semi-quantitatively analyzed.Results: This study included 14 patients (average age was 38.6). Physiological ovarian uptake was mostly unilateral, and there was no significant difference in SUVmax between the left and right sides (FDGt = 0.272, FAPIt = 0.592). The ovary SUVmax of FDG (4.89 ± 1.84) was statistically significantly higher than that of FAPI (1.53 ± 0.37). The Le/Li ratio on FDG is 3.38 ± 1.81, TBR is 5.81 ± 1.98, while the Le/Li ratio on FAPI is 3.57 ± 1.26, TBR is 0.94 ± 0.19.Conclusion: Our research shows that ovarian functional or pathological changes can be manifested as FDG avid, while 68Ga-DOTA-FAPI-04 has no physiological accumulation in the ovary and is not affected by the menstrual cycle. Therefore, 68Ga-DOTA-FAPI-04 has unique advantages in the diagnosis of ovarian diseases, and can identify them early and accurately.

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Section: Introductionmentioning

confidence: 99%

68Ga-DOTA-FAPI-04 PET/CT as a Promising Tool for Differentiating Ovarian Physiological Uptake: Preliminary Experience of Comparative Analysis With 18F-FDG

et al. 2021

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“…However, due to the pathological characteristics of glucose metabolism, [18F]-FDG is highly distributed in normal organs including the brain, heart and liver [1][2][3] . At the same, [18F]-FDG PET/CT lacks specificity in differentiating inflammation [4][5][6] . Many physiological variations and pitfalls of whole-body [18F]-FDG PET/CT imaging have been reported [7][8][9] .…”

mentioning

confidence: 99%

Evaluating the physiological metabolism of the ovaries with [18F]-FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT

Wang,

Liu,

Yang

et al. 2024

Preprint

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Objective: The purpose of this study was to investigate the role of [68Ga]Ga-DOTA-FAPI-04 PET/CT in evaluating ovarian physiological FDG uptake. We also prospect future research. Design: Retrospective study. Setting: Nuclear Medicine Department of the Affiliated Hospital of Southwest Medical University. Sample: female patients who underwent simultaneous [18F]-FDG PET/CT and [68Ga]Ga-DOTA-FAPI-04 PET/CT examinations in the Affiliated Hospital of Southwest Medical University from September of 2020 to January of 2021. Methods: We reviewed the data of 78 female patients who underwent [18F]-FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT scanning within 3 days and selected those whose ovaries showed abnormal FDG activity. Patients with ovarian lesions confirmed by pathological biopsy or clinical follow-up were excluded, and the uptake of imaging agents was semi-quantitatively analyzed. Main outcome measures: Characteristics of ovarian imaging agent uptake on 18F-FDG and 68Ga-DOTA-FAPI-04 PET/CT images, pathological data, and clinical follow-up evidence. Results: This study included 14 patients who were diagnosed with physiological ovarian FDG uptake by pathology or at least 6 months follow-up. The average age was 38.6 years old (range, 19-52). Physiological ovarian uptake of FDG was more common in unilateral cases, with a median SUVmax of 4.8±1.8 (range, 2.7-8.2). There was no ovarian uptake of the imaging agent on FAPI imaging. Conclusion: Our study showed that FDG, but not FAPI, uptake increased in normal ovaries due to the influence of the menstrual cycle. [68Ga]Ga-DOTA-FAPI-04 PET/CT has a unique advantage in differentiating the ovarian physiological [18F]-FDG uptake and can better identify ovarian lesions.

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Imaging of diffuse fibroepithelial polyps on surgical free flap in oral cancer patients: two case reports

et al. 2023

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Scrotal Fibroepithelial Polyp With Acute and Chronic Inflammation Mimics Malignancy on 18F-FDG PET/CT Imaging

Cited by 3 publications

References 25 publications

68Ga-DOTA-FAPI-04 PET/CT as a Promising Tool for Differentiating Ovarian Physiological Uptake: Preliminary Experience of Comparative Analysis With 18F-FDG

68Ga-DOTA-FAPI-04 PET/CT as a Promising Tool for Differentiating Ovarian Physiological Uptake: Preliminary Experience of Comparative Analysis With 18F-FDG

Evaluating the physiological metabolism of the ovaries with [18F]-FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT

Imaging of diffuse fibroepithelial polyps on surgical free flap in oral cancer patients: two case reports

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