Scropolioside B Inhibits IL-1<i>β</i>and Cytokines Expression through NF-<i>κ</i>B and Inflammasome NLRP3 Pathways

Zhu, Tiantian; Zhang, Liuqiang; Ling, Shuang; Duan, Ju; Qian, Fei; Li, Yiming; Xu, Jin-Wen

doi:10.1155/2014/819053

Cited by 50 publications

(32 citation statements)

References 37 publications

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“…Interestingly, the IL-1β mRNA level was significantly decreased not only during the period that the NF-κB level increased but also when the level of NF-κB began to decrease at 90 days. Similarly, Zhu et al have observed an increase in the transcription of NF-κB and an association between the increased NF-κB expression and an increased level of IL-1β [23]. Thus, these results show the persistence of the effect of NF-κB on IL-1β [24,25].…”

Section: Discussionsupporting

confidence: 66%

Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks

Zhang

Zhao

Guo

et al. 2015

Biol Trace Elem Res

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Arsenic (As) is a trace element widely found in nature. It exists in several forms, including organic arsenic, inorganic arsenic, and trivalent arsenic, the most toxic. Arsenic trioxide (As2O3) is widespread in nature. This form tends to accumulate in animals and humans and therefore has a potential harm for them. Cytokines play essential roles in the immune response and inflammation. Although the importance of cytokines in the responses to arsenic exposure has been demonstrated in many types of mammals, the function of these in poultry, especially in chickens, remains unclear. The purpose of the present study was to examine the effect of As2O3 exposure on cytokines in cock livers. In this study, 72 1-day-old male Hy-line cocks were randomly divided into four groups including the control group, low-As group, middle-As group, and high-As group. The livers were collected on days 30, 60, and 90 of the experiment. The levels of nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-12 beta (IL-12β), and interleukin-1 beta (IL-1β) mRNA in the livers of the cocks were measured using real-time PCR. The results showed that the expression levels of IL-6, IL-8, TNF-α, and NF-κB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12β, and IL-1β were decreased in the experiment. The information regarding the effects of As2O3 on cytokine mRNA expression generated in this study will be important information for arsenic toxicology evaluation.

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Section: Discussionsupporting

confidence: 66%

Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks

Zhang

Zhao

Guo

et al. 2015

Biol Trace Elem Res

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“…NF-kB can stimulate the expression of cytokines such as TNF-a and IL-1b. These cytokines are resistant to NF-kB, further stimulate NF-kB and aggravate the occurrence of inflammatory reactions (Zhu et al, 2014). In 2006, Duman RS proposed the hypothesis of neurotrophic factors in depression, suggesting that BDNF can promote the growth of sudden contact and maintain the survival of neurons.…”

Section: Discussionmentioning

confidence: 99%

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

et al. 2020

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Depression is becoming a major public health concern worldwide. Si-Ni-San (SNS) is a famous formula in Traditional Chinese Medicine (TCM) with potent antidepressant effects. However, the antidepressant mechanism of SNS has not been clearly elucidated. This study was performed to verify whether the antidepressant effects of SNS were related to its anti-inflammatory effects, the levels of brain-derived neurotrophic factor (BDNF) and Cytochrome P450 (CYP450) enzymatic activity. In our study, behavioral tests such as the forced swim test, sucrose preference test and open-field test were evaluated to ensure the establishment of depressive rats. The levels of IL-1b, IL-6, and TNF-a in the serum, liver, and hippocampus of rats were measured by enzyme-linked immunosorbent assays (ELISA). Furthermore, the key proteins NF-kB, BDNF, and TrkB were analyzed by Western blot (WB) analysis in the hippocampus. In addition, CYP450 enzymatic activity analysis was performed using LC-MS/MS in conjunction with drug and statistics (DAS 3.0) after oral administration of six probe drugs. Our results showed that SNS attenuated reserpineinduced increases in IL-1b, IL-6, and TNF-a expression in the serum, liver, and hippocampus. The levels of NF-kB, BDNF, and TrkB in the hippocampus of depressive rats were also altered. According to the pharmacokinetic parameters, SNS had moderate inhibitory effects in the reserpine-induced depression model on CYP1A2, CYP2D1, CYP2E1, and CYP3A2, but no significant metabolic changes to CYP2C6 and CYP2D2. These findings suggested that SNS has a protective effect on reserpine-induced depressive rats, which may be related to the improvement of the inflammatory factors, the level of BDNF and the activity of CYP450 enzymes.

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“…Inflammasome NLRP3 is a component of innate immune system involved in the maturation of pro‐inflammatory cytokine IL‐1β. Scrophuloside B‐mediated inhibition of inflammasome NLRP3 expression via discussed pathway hinders IL‐1β secretion . Since these mentioned pro‐inflammatory mediators are critically involved in the pathophysiology of diabetic retinopathy, their inhibition may potentially prevent the progression of this complication.…”

Section: Chinese Herbs As Potential Antidiabetic Retinopathy Therapymentioning

confidence: 99%

Chinese herbal drugs for the treatment of diabetic retinopathy

Behl

Kotwani

2017

Journal of Pharmacy and Pharmacology

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Objectives To explore the various pharmacological actions and the molecular mechanisms behind them by which Chinese herbs tend to lower the risk of developing microvascular diabetic complications in retina and prevent its further progression. Key findings Several Chinese herbs, indeed, elicit potent anti-inflammatory, antioxidant, anti-angiogenic, anti-apoptotic, peroxisome proliferator-activated receptor-gamma receptor agonistic, platelet-activating factor antagonistic, aldose reductase inhibitory and various other beneficial pharmacological activities, required to counteract the pathological conditions prevalent in retina during diabetes. Summary Chinese herbs can potentially be used for the treatment/prevention of diabetic retinopathy owing to the virtue of numerous properties by which they alleviate several hyperglycaemia-induced pathological occurrences in retina. This would provide a natural and safe therapy for diabetic retinopathy, which currently is clinically limited to destructive techniques like laser photocoagulation and vitrectomy.

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Scropolioside B Inhibits IL-1βand Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways

Cited by 50 publications

References 37 publications

Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks

Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

Chinese herbal drugs for the treatment of diabetic retinopathy

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