ScRNA-seq reveals novel immune-suppressive T cells and investigates CMV-TCR-T cells cytotoxicity against GBM
Xinmiao Long,
Zuping Zhang,
Yuzhe Li
et al.
Abstract:BackgroundGlioblastoma (GBM) is a fatal primary brain malignancy in adults. Previous studies have shown that cytomegalovirus (CMV) is a risk factor for tumorigenesis and aggressiveness for glioblastoma. However, little is known about how CMV infection affects immune cells in the tumor microenvironment of GBM. Furthermore, there has been almost no engineered T-cell receptor (TCR)-T targeting CMV for GBM research to date.MethodsWe evaluated the CMV infection status of patients with GBM’s tumor tissue by immune e… Show more
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