Screening whole spine magnetic resonance imaging in multiple myeloma

Wight, Joel; Stillwell, A.; Morris, Edward S.; Grant, Bonnie; Lai, Hock Choong; Irving, Ian

doi:10.1111/imj.12789

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Conversely, Wight et al () evaluated the detection rate of spinal myelomatous lesions in SMRI compared with Whole‐Body MDCT in order to assess accuracy in staging. In their conclusions they asserted that screening by SMRI in asymptomatic patients had a low yield for focal spinal disease (recommending SMRI evaluation only in symptomatic patients) and that in patients with symptomatic myeloma requiring therapy with no clinical reason to evaluate the spine, SMRI evaluation is of questionable value as it adds little clinically useful information that will alter their management.…”

Section: Discussionmentioning

confidence: 99%

“…The detection of lytic bone lesions represents a criterion defining a symptomatic MM that requires treatment, even in the absence of clinical symptoms (Lecouvet et al , ; Mahnken et al , ; Derlin & Bannas, ). The axial skeleton is the most common site of myelomatous lesions, arising in 90% of patients during the course of their disease, with a various spectrum of presentation, such as myeloma‐induced osteoporosis, osteolysis or compression fractures and, in almost 20% of the cases, spinal cord compression may occur (Bird et al , ; Wight et al , ).…”

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confidence: 99%

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Diagnostic value of whole-body ultra-low dose computed tomography in comparison with spinal magnetic resonance imaging in the assessment of disease in multiple myeloma

et al. 2017

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This study compared the diagnostic value of Whole-Body Ultra Low-Dose computed tomography (WBULDCT) with that of Spinal Magnetic Resonance Imaging (SMRI) in identification of spinal bone marrow involvement in patients with Multiple Myeloma (MM). Thirty-five patients with histologically proven MM underwent WBULDCT and dedicated SMRI. Unenhanced WBULDCT was performed on a 256-slice scanner, with 120 kV and 40 mAs. SMRI was performed on a 1·5T magnet, with T1-turbo spin echo and T2-short tau inversion recovery sequences on sagittal plane. WBULDCT was compared with SMRI in terms of lesion detection, pattern and bone marrow involvement. The overall concordance between WBULDCT and SMRI in lesion detection was 76·7%, detecting (25/35) or excluding (8/35) involvement of the axial skeleton, while in 2/35 patients WBULDCT and SMRI were discordant in terms of axial skeleton involvement. The concordance in spinal distribution of lesions was 61·6% on cervical, 71·5% on dorsal, 86·4% on lumbar and 94·4% on sacral, while for the pattern of disease, it was 56·1% for the focal and 88·7% for the combined pattern. Cohen's kappa index was 0·85 (P < 0·001) assessing an excellent agreement. WBULDCT represents a useful diagnostic tool in the detection of spinal involvement of MM patients, offering detailed information about extra-axial involvement, which could be potentially missed with dedicated SMRI.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Diagnostic value of whole-body ultra-low dose computed tomography in comparison with spinal magnetic resonance imaging in the assessment of disease in multiple myeloma

et al. 2017

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“…Due to the multiple vertebral involvements, spinal MRI -cervical, thoracic and lumbarshould be performed to ensure that the treatment can be planned correctly. Because X-ray or CT cannot be seen lesions can also be detected (20).…”

Section: Discussionmentioning

confidence: 99%

Omurilik Basısı Nedeniyle Dekompresyon Uygulanan Multipl Miyelom Olgularının Değerlendirilmesi

Eren¹,

Güleç²,

Güzey³

et al. 2020

Osmangazi̇ Journal of Medicine

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Multiple myeloma accounts for 5-10% of all cancers associated with spinal cord compression. In this study, the surgical results of patients with multiple myeloma operated for spinal epidural compression were evaluated. Between 2011 and 2017, twenty-one patients were operated by posterior decompression for spinal cord compression, whose pathological diagnosis was multiple myeloma in our hospital's neurosurgery clinic included in the study. Demographic, clinical and radiological features of the patients and their status after surgery were examined. The mean age of the 21 patients was 62.6 ± 9.3. Thirteen patients were male and 8 were female. When the chain isotype was found in protein electrophoresis, the maximum IgG (52.4%) was present. The mean Karnofsky performance of the patients was 46.2 ± 17.7. Significant improvement was observed in the postoperative motor strength of the patients (p = 0.0001). In addition, postoperative pain-VAS scores-was significantly reduced (p = 0.0001). 90% of the patients were operated under emergency conditions. The number of patients who were operated stabilization with decompression was 5 (23.8%). When the radiological data were analyzed, the mean amount of compression in the operated vertebrae was 33.1% and the mean shrinkage rate of the tumor was 65.4%. Although spinal canal narrowing was observed in all patients, compression fracture was present in 16 patients (76.2%). The mean follow-up period was 22.3 months. During the follow-up period, 9 patients died, 5 of them were in the first year. Postoperative complications were wound infection in 2 patients, chronic renal failure in 1 patient and bilateral pleural effusion in 1 patient. Surgical treatment should be the first option if there is a progressive neurological deficit in patients with spinal cord compression due to multiple myeloma. With surgical treatment, decompression of the spinal cord compression, pain control and stabilization can be performed.

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Supportive Care in Multiple Myeloma

Doshi¹,

Noff

Roodman

2017

Neoplastic Diseases of the Blood

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Multiple myeloma is one of the most commonly diagnosed blood cancers. Due to the introduction of new therapies in recent years, there has been significant progress in treating myeloma. Even so, with the introduction of new groups of drugs, there have been some adverse events. In addition to anti-myeloma treatment, patients require supportive therapies. This article presents the principles of supportive treatment in emergencies and discusses the toxicity associated with the use of new groups of drugs.

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Screening whole spine magnetic resonance imaging in multiple myeloma

Cited by 3 publications

References 12 publications

Diagnostic value of whole-body ultra-low dose computed tomography in comparison with spinal magnetic resonance imaging in the assessment of disease in multiple myeloma

Diagnostic value of whole-body ultra-low dose computed tomography in comparison with spinal magnetic resonance imaging in the assessment of disease in multiple myeloma

Omurilik Basısı Nedeniyle Dekompresyon Uygulanan Multipl Miyelom Olgularının Değerlendirilmesi

Supportive Care in Multiple Myeloma

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