Screening Tests to Evaluate Distant Metastases in Head and Neck Cancer

Ferlito, Alfio; Buckley, J. Graham; Rinaldo, Alessandra; Mondin, Vanni

doi:10.1159/000055741

Cited by 16 publications

(12 citation statements)

References 26 publications

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“…Distant metastatic clearly affect the prognosis of HNSCCs and if not present at initial presentation it usually becomes apparent within two years [2]. Even so their clinicopathological predictive factors of occurrence are the site of the primary tumor (oropharynx, hypopharynx and larynx), multilevel nodal involvement in neck and primary tumor invasion into muscular, bone or cartilage ; metastatic screening by 18 [F]-FDG PET/CT can detect them early, before the onset of medical complications [3]. Detection of occult disseminated disease without curative options allow avoiding all futile treatment, counseling patients about prognosis and optimizing their quality of life [4].…”

Section: Discussionmentioning

confidence: 99%

101 spots: find the primary site

Bera¹,

Malouf²,

Yeni³

et al. 2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Figure 1A), in particular from the oral cavity to pyriform sinus ( Figure 1B), in the subcutaneous tissues ( Figure 1C), on bone, pancreas ( Figure 1D) and a moderate uptake on the right upper lung lobe probably corresponding to a pleomorphic PSC recurrence ( Figure 1E, 1F). Thus these findings have suggested a distant metastatic relapse of the PSC associated with a loco-regional recurrence of OSCC. Surprisingly, histological analysis of subcutaneous biopsies ( Figure 1G) concluded a well-differentiated SCC and immunostaining for thyroid transcription factor-1 (TTF-1) was negative. IJCRI publishes Review DIsCUssIoNPulmonary sarcomatoid carcinoma is a rare, poorly differentiated subtype of non-small cell lung cancer accounting for 0.1-0.4% of all lung malignancies. They occur mostly in smoking males, at an average age of 60 years. With a high frequency of local recurrence and distant metastatio, they are responsible of an aggressive clinical course. Microscopically, this poor prognostic disease is the result of a biphasic proliferative malignant cells with both carcinoma and sarcomatoid components. Immunohistochemically, TTF-1, a specific marker of thyroid and pulmonary tumors such as adenocarcinoma and small cell carcinoma, is find to be positive in more than 50% of PSCs [1]. Head and neck squamous cell carcinoma (HNSCC), as far as they are concerned, preferentially metastasise to cervical lymph nodes. They have an uncommon hematogenous spread varying from 4.2-23.8%, up to 57% at autopsies on the lungs (80%), mediastinal nodes (34%), bone (31%) and liver (31%). Distant metastatic clearly affect the prognosis of HNSCCs and if not present at initial presentation it usually becomes apparent within two years [2]. Even so their clinicopathological predictive factors of occurrence are the site of the primary tumor (oropharynx, hypopharynx and larynx), multilevel nodal involvement in neck and primary tumor invasion into muscular, bone or cartilage ; metastatic screening by 18 [F]-FDG PET/CT can detect them early, before the onset of medical complications [3]. Detection of occult disseminated disease without curative options allow avoiding all futile treatment, counseling patients about prognosis and optimizing their quality of life [4]. Cancer-related hypercalcemia is most common in patients with lung, breast, head and neck and kidney cancer. It could be related either to osteolysis of the severe bone metastases -that was probably the reason for this atypical patient-or a paraneoplastic syndrome. Having a strong correlation with the stage of the pr...

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Section: Discussionmentioning

confidence: 99%

101 spots: find the primary site

Bera¹,

Malouf²,

Yeni³

et al. 2015

IJCRI

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“…La TEP-FDG, présentant une sensibilité de 92 %, peut compléter l'imagerie en coupes en cas de doute sur la scanographie ou l'IRM [13]. La surveillance par radiographie pulmonaire n'a pas montré de bénéfice en termes de prise en charge mais son faible coût et sa facilité de réalisation font qu'elle est souvent proposée à un rythme annuel [10,24]. L'existence d'une anomalie sur le cliché thoracique doit conduire à la réalisation d'une scanographie et tout nodule évolutif ou supérieur à 1 cm doit faire l'objet d'une concertation pluridisciplinaire.…”

Section: éValuation Du Contrôle Carcinologiqueunclassified

“…La probabilité de survie globale est de 26 % à cinq ans après une seconde localisation contre 69 % après un premier cancer [28,29]. Le traitement conservateur ou non de la localisation initiale ne semble pas influer sur le risque de développer une seconde tumeur [24].…”

Section: Dépistage Des Seconds Cancersunclassified

Suivi clinique et paraclinique après radiothérapie pour un cancer des voies aérodigestives supérieures

Clément-Colmou

Troussier

Bardet

et al. 2015

Cancer/Radiothérapie

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“…The current Dutch guideline does not consider a diagnostic search for a synchronous second tumor in all HNSCC patients due to the low incidence. [17,18] However, the presence of a second primary pulmonary tumor will have a profound effect on treatment choices and planning. This is a valid reason for screening more extensively patients with newly diagnosed SCC of the oral cavity.…”

mentioning

confidence: 99%

Strategies for patients with newly diagnosed oral squamous cell carcinoma and a positive chest CT. A cohort study on the effects on treatment planning and incidence

Jaspers¹,

Witjes²,

Groen³

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Please cite this article as: Jaspers GW, Witjes MJ, Groen HJ, Groen H, Rödiger LA, Roodenburg JL. Strategies for patients with newly diagnosed oral squamous cell carcinoma and a positive chest CT. A cohort study on the effects on treatment planning and incidence, European Journal of Surgical Oncology (2010Oncology ( ), doi: 10.1016Oncology ( /j.ejso.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In 20 (13%) patients chest abnormalities were observed on CT scan of the chest and in 6 (4%) patients malignancy was pathologically confirmed. Both pulmonary second primary tumors and pulmonary metastases were independent of stage of oral malignancy. We found that additional diagnostic procedures did not significantly lengthen the time interval between first consult and start of treatment. The cost of the screening for pulmonary malignancies in the group was € 8.214 per observed pulmonary malignancy.We advocate that CT imaging of the chest should be routinely performed in the diagnostic work up of all patients with a newly discovered SCC of the oral cavity, irrespective of the tumor stage of the oral malignancy.

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Screening Tests to Evaluate Distant Metastases in Head and Neck Cancer

Cited by 16 publications

References 26 publications

101 spots: find the primary site

101 spots: find the primary site

Suivi clinique et paraclinique après radiothérapie pour un cancer des voies aérodigestives supérieures

Strategies for patients with newly diagnosed oral squamous cell carcinoma and a positive chest CT. A cohort study on the effects on treatment planning and incidence

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