Screening soft materials for their effect on skin barrier function by high throughput experimentation

Newsam, J. M.; King‐Smith, Dominic; Jain, Amit; Karande, Pankaj; Feygin, Ilya; Burbaum, Jonathan J.; Gowrishankar, Thiruvallur R.; Sergeevа, Maria S.; Mitragotri, Samir

doi:10.1039/b416210b

Cited by 10 publications

(8 citation statements)

References 80 publications

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“…Hydrophobic drugs with low molecular weight transfer best through the skin, and surfactants may be added to increase the skin permeability. [154] Hydrogels have been used to deliver anesthetics in wound dressings. [155] The preparation and properties of hydrogels for iontophoretic (electrically driven) transdermal delivery have been reviewed.…”

Section: Drug-delivery Systemsmentioning

confidence: 99%

Hydrogels for Soft Machines

2009

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Hydrogels have applications in surgery and drug delivery, but are never considered alongside polymers and composites as materials for mechanical design. This is because synthetic hydrogels are in general very weak. In contrast, many biological gel composites, such as cartilage, are quite strong, and function as tough, shock‐absorbing structural solids. The recent development of strong hydrogels suggests that it may be possible to design new families of strong gels that would allow the design of soft biomimetic machines, which have not previously been possible.

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Section: Drug-delivery Systemsmentioning

confidence: 99%

Hydrogels for Soft Machines

2009

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“… 3 , 10 In addition, in vitro models can be used to evaluate a number of combinations of experimental parameters, which is often not achievable with animal models. 40 , 41 These models are commonly used for basic science, pharmaceutical research and development, toxicology, and permeability studies. The use of both primary and immortalized cell culture models of ocular barriers is described in the literature.…”

Section: In Vitro Cell-based Modelsmentioning

confidence: 99%

In VitroCell Models for Ophthalmic Drug Development Applications

Shafaie

Hutter

Cook

et al. 2016

BioResearch Open Access

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Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.

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“…In vitro models can be used to assess a large number of different combinations of experimental parameters. 1 Such high-throughput testing is often not feasible with animal-based models.…”

Section: Introductionmentioning

confidence: 99%