Screening, separation and identification of metal-chelating peptides for nutritional, cosmetics and pharmaceutical applications

Echavarría, Jairo Andrés Camaño; El Hajj, Sarah; Irankunda, Rachel; Selmeczi, Katalin; Paris, Cédric; Udenigwe, Chibuike C.; Canabady-Rochelle, Laetitia

doi:10.1039/d3fo05765h

Food Funct.

2024

DOI: 10.1039/d3fo05765h

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Screening, separation and identification of metal-chelating peptides for nutritional, cosmetics and pharmaceutical applications

Jairo Andrés Camaño Echavarría,

Sarah El Hajj,

Rachel Irankunda

et al.

Abstract: Metal-chelating peptides, which form metal-peptide coordination complexes with various metal ions, can be used as biofunctional ingredients notably to enhance human health and prevent diseases. This review aims to discuss...

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Cited by 2 publications

References 231 publications

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Exploring the potential of plant-derived metal ion binding peptides: Preparation, structure-activity relationship, and biological activities

Li,

Ma,

Yang

et al. 2024

Trends in Food Science & Technology

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Exploring the potential of plant-derived metal ion binding peptides: Preparation, structure-activity relationship, and biological activities

Li,

Ma,

Yang

et al. 2024

Trends in Food Science & Technology

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Preparation, Characterization and Stability of Calcium-Binding Peptides Derived from Chicken Blood

Yang,

Shi,

Zhou

et al. 2024

Foods

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Calcium-binding peptides have gained significant attention due to their potential applications in various fields. In this study, we aimed to prepare, characterize, and evaluate the stability of calcium-binding peptides derived from chicken blood. Chicken hemoglobin peptides (CPs) were obtained by protease hydrolysis and were applied to prepare chicken hemoglobin peptide–calcium chelate (CP-Ca). The preparation conditions were optimized, and the characteristics and stability of CP-Ca were analyzed. The optimal chelating conditions were determined by single-factor and response surface tests, and the maximum calcium ion chelating rate was 77.54%. Amino acid analysis indicated that glutamic acid and aspartic acid motifs played an important role in the chelation of the calcium ions and CP. According to the characterization analysis, CP-Ca was a different substance compared with CP; calcium ions chelated CPs via the sites of carbonyl oxygen, carboxyl oxygen, and amino nitrogen groups; and after the chelation, the structure changed from a smooth homogeneous plate to compact granular. The stability analysis showed that CP-Ca was stable at different temperatures, pH, and gastrointestinal conditions. The study indicates that chicken blood is a promising source of peptide–calcium chelates, providing a theoretical basis for application in functional foods and improving the utilization value of chicken blood.

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Screening, separation and identification of metal-chelating peptides for nutritional, cosmetics and pharmaceutical applications

Abstract: Metal-chelating peptides, which form metal-peptide coordination complexes with various metal ions, can be used as biofunctional ingredients notably to enhance human health and prevent diseases. This review aims to discuss...

Cited by 2 publications

References 231 publications

Exploring the potential of plant-derived metal ion binding peptides: Preparation, structure-activity relationship, and biological activities

Exploring the potential of plant-derived metal ion binding peptides: Preparation, structure-activity relationship, and biological activities

Preparation, Characterization and Stability of Calcium-Binding Peptides Derived from Chicken Blood

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