Screening pulmonary hypertension patients for depression

McCollister, Deborah H.

doi:10.1111/j.1742-1241.2011.02821.x

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…This prospective study confirms the previously reported high prevalence of mental disorders in PAH [6,9,28-30] and shows a similar prevalence for inoperable CTEPH patients. The rate of moderate to severe major depressive disorder in PAH has been estimated to be 20%-50% [9,29,31] and was similar to the prevalence in patients with left-heart failure (30% major depression) [32].…”

Section: Discussionsupporting

confidence: 91%

Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Harzheim

Klose²,

Pinado

et al. 2013

Respir Res

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BackgroundThe objective of this prospective study was to assess the prevalence of anxiety and depression disorders and their association with quality of life (QoL), clinical parameters and survival in patients with pulmonary hypertension (PH).MethodsWe prospectively assessed 158 patients invasively diagnosed with pulmonary arterial hypertension (n = 138) and inoperable chronic thromboembolic PH (n = 20) by clinical measures including quality of life (QoL, SF-36 questionnaire), cardiopulmonary exercise testing and six minute walking distance and by questionnaires for depression (PHQ-9) and anxiety (GAD-7). According to the results of the clinical examination and the questionnaires for mental disorders (MD) patients were classified into two groups, 1) with moderate to severe MD (n = 36, 22,8%), and 2) with mild or no MD (n = 122). Patients were followed for a median of 2.7 years. Investigators of QoL, SF-36 were blinded to the clinical data.ResultsAt baseline the 2 groups did not differ in their severity of PH or exercise capacity. Patients with moderate to severe MD (group 1) had a significantly lower QoL shown in all subscales of SF-36 (p < 0.002). QoL impairment significantly correlated with the severity of depression (p < 0.001) and anxiety (p < 0.05). During follow-up period 32 patients died and 3 were lost to follow-up. There was no significant difference between groups regarding survival. Only 8% of the patients with MD received psychopharmacological treatment.ConclusionAnxiety and depression were frequently diagnosed in our patients and significantly correlated with quality of life, but not with long term survival. Further prospective studies are needed to confirm the results.

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Section: Discussionsupporting

confidence: 91%

Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Harzheim

Klose²,

Pinado

et al. 2013

Respir Res

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“…Several studies have shown that depression and anxiety are frequently reported symptoms in PH [9,10,11,12,14], and thus screening for mental disorders has been recommended [25,26]. …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Anxiety and Depression in Pulmonary Hypertension and Changes during Therapy

et al. 2016

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Background: Pulmonary hypertension (PH) leads to reduced health-related quality of life (HRQoL). Objective: To investigate the prevalence and course of anxiety and depression and their association with HRQoL, disease severity and survival in PH. Methods: 131 PH patients (91 pulmonary arterial, 30 chronic thromboembolic, 10 due to lung disease; 84 female, 47 male) had repeated assessments with the Hospital Anxiety and Depression Scale (HADS), HRQoL, six-minute walk distance and WHO functional class during a mean course of 16 ± 12 months. Results: Among the 49 incident and 82 prevalent PH patients, the HADS score was positive in 53%/21% (depression), 51%/24% (anxiety) and 63%/26% (total score) (all p < 0.05). The HADS score was improved at the second assessment in incident patients. The HADS score correlated with HRQoL at all consecutive assessments and with functional class until the third assessment, but not with baseline hemodynamics, age or gender. Conclusion: Mood disorders remain underdiagnosed in PH. The higher prevalence of anxiety/depression in incident versus prevalent patients and the improvement over time may indicate an amelioration of mood disorders after PH diagnosis and treatment.

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“…The complex nature of PAH, an uncertain future, and a lack of cure can impel feelings of being overwhelmed and the inability to maintain regular social activities. [ 6 7 ] As a result, patients report restrictions in their ability to perform daily tasks such as working, traveling, shopping, and household chores. [ 8 ] A recent international survey of PAH patients found them to have feeling of worthlessness (22%), frustration (35%), anger (24%), and little pleasure in activities (25%) that they enjoyed prior to PAH diagnosis.…”

Section: Research In Pulmonary Arterial Hypertension and Depressionmentioning

confidence: 99%

“…A lack of proper training skills in treating physicians may also play a role in not detecting underlying depression. [ 7 ]…”

Section: Screening For Depressionmentioning

confidence: 99%

Depression in pulmonary arterial hypertension: An undertreated comorbidity

et al. 2016

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Pulmonary arterial hypertension (PAH) is a debilitating condition leading to progressive decline in functional capacity. As a result, PAH can lead to psychological impairment that can impact the overall disease status. The medical community has developed several screening questionnaires in order to assess depression in their patients allowing physicians to be at the forefront of recognizing clinical depression. There is a suggestion that depression symptomatology is more prevalent in the PAH population. The aim of this article is to review the current thought process about diagnosis and management of depression in PAH patients.

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Screening pulmonary hypertension patients for depression

Cited by 7 publications

References 15 publications

Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Prevalence of Anxiety and Depression in Pulmonary Hypertension and Changes during Therapy

Depression in pulmonary arterial hypertension: An undertreated comorbidity

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