Screening Phytochimique, Étude Toxicologique, Évaluation des Activités Antiplasmodiale et Antiradicalaire de la Tige Feuillée de Senna occidentalis Linn (Fabaceae)

Abstract

The valorization of traditional medicine involves pharmacological researches on medicinal plants. Thus, to effectively fight malaria, the major public health problem in Togo, pharmacological, phytochemical and toxicological studies were carried out on Senna occidentalis. The compilation of the results on ethnobotanical surveys carried out at CERFOPLAM from 2010 to 2013 on malaria and its affiliated symptoms lead to selecting Senna occidentalis in order to confirm the characteristics attributed to it. Various tests were carried out on aqueous and hydroethanolic extracts 50:50 of the plant. The antiplasmodial activity in vitro was carried out on cultivated parasites (Plasmodium falciparum: wild strain) according to the optical micro-test. Phytochemical screening was characterized by thin layer chromatography followed by colorimetric tests. The preliminary toxicity was carried out on Artemia salina then the in vitro antioxidant potential of the extracts was measured by the reduction test of the 2, 2-diphenyl-1-picryl

Antiplasmodial, Antioxidant, and Cytotoxic Activity of Bridelia micrantha a Cameroonian Medicinal Plant Used for the Treatment of Malaria

“…It appears from this study that the ethanolic extract was more active than the aqueous extract. Our results are similar to those obtained by Tomani et al [28] with Eriosema montanum Baker f. roots on Plasmodium 3D7 strain which had obtained an IC 50 of 17:68 ± 4:030 μg/ml of ethanolic extract and different from that obtained by Esseh et al [29] which had an IC 50 of 91:08 ± 0:61 μg/ml of aqueous extract. This difference can be explained by the type of extract, and the strain of Plasmodium used in this study, as well as the geographical location of the plant, may have had an impact on the observed difference.…”