Screening of Venda medicinal plants for antifungal activity against Candida albicans

Steenkamp, Vanessa; Fernandes, Antônio Carlos; Rensburg, C. E. J. Van

doi:10.1016/j.sajb.2006.11.003

Cited by 58 publications

(38 citation statements)

References 15 publications

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“…For instance three to four cupfuls per day is given to adults and one teaspoon 3 times daily for children. This observation supported the reports of Steenkamp et al (2007) and Otang et al (2011), who revealed thatwater extracts tested against fungal strains did not give any activity, probably due to its polarity or the low the dosage used.…”

Section: Resultssupporting

confidence: 91%

Chemical composition profiling and antifungal activity of the essential oil and plant extracts of Mesembryanthemum edule (L.) bolus leaves

Omoruyi¹,

Afolayan²,

Bradley³

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Essential oil from Mesembryanthemum edule leaves have been used by the Eastern Cape traditional healers for the treatment of respiratory tract infections, tuberculosis, dysentery, diabetic mellitus, laryngitis and vaginal infections. The investigation of bioactive compounds in the essential oil of this plant could help to verify the efficacy of the plant in the management or treatment of these illnesses. Materials and methods: Various concentrations of the hydro-distilled essential oil, ranging from 0.005-5 mg/ml, were tested against some fungal strains, using the micro-dilution method. Minimum inhibitory activity was compared with four other different crude extracts of hexane, acetone, ethanol and aqueous samples from the same plant. The chemical composition of the essential oil, hexane, acetone and ethanol extracts was determined using GC-MS. Result: GC/MS analysis of the essential oil resulted in the identification of 28 compounds, representing 99.99% of the total oil. Phytoconstituents of hexane, acetone and ethanol extracts yielded a total peak chromatogram of fifty nine compounds. A total amount of 10.6% and 36.61% of the constituents were obtained as monoterpenes and oxygenated monoterpenes. Sesquiterpene hydrocarbons (3.58%) were relatively low compared to the oxygenated sesquiterpenes (9.28%), while the major concentrated diterpenes and oxygenated diterpenes were 1.43% and 19.24 %, respectively and phytol 12.41%. Total amount of fatty acids and their methyl esters content, present in the oil extract, were found to be 19.25 %. Antifungal activity of the oil extract and four solvent extracts were tested against five pathogenic fungal strains. The oil extract showed antifungal activity against Candida albican, Candida krusei, Candida rugosa, Candida glabrata and Cryptococcus neoformans with MIC ranges of 0.02-0.31 mg/ml. Hexane extract was active against the five fungal strains with MICs ranging between 0.02-1.25 mg/ml. Acetone extracts were active against C. krusei only at 0.04mg/ml. No appreciable antifungal activity was found in either ethanol or water extracts when compared with commercial antibiotics. Conclusion: The profile of chemical constituents found in M. edule essential oil and its antifungal properties support the use of M. edule by traditional healers as well as in the pharmaceutical and food industries as a natural antibiotic and food preservative.

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Section: Resultssupporting

confidence: 91%

Chemical composition profiling and antifungal activity of the essential oil and plant extracts of Mesembryanthemum edule (L.) bolus leaves

Omoruyi¹,

Afolayan²,

Bradley³

2014

Afr. J. Trad. Compl. Alt. Med.

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“…Also medicinal plants are used in different disease treatments and they are popular all over the world [7]. Different studies showed anti-fungal activity of medicinal plants against C. albicans [1]. Nchu et al in South Africa showed that the leaf extracts of Markhamia obtusifolia had effects against C. albicans in vitro [23].…”

Section: Discussionmentioning

confidence: 99%

“…So it might be with increasing the amount of extract, diffusion of extract in medium rises and it shows greater antifungal effect [2]. Steenkamp et al in South Africa showed that crude methanol and water extracts of 32 plant species inhibited C. albicans growth [1]. In Uruguay, Diaz-Dellavalle et al determined that aqueous extract of 10 plant species exhibit anti-fungal activity against Alternaria spp.…”

Section: Discussionmentioning

confidence: 99%

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In vitro Antifungal Activity of Cucumis melo on Candida albicans

Azizi

Rouhi

Yahyayi

2015

Zahedan J Res Med Sci

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Background: With respect to the emergence of susceptibility of some fungi to antifungal agents, making use of medicinal plants is progressing. Objectives: The aim of this study was to verify the anti-fungal characteristics of mature and immature Cucumis melo fruit on Candida albicans. Materials and Methods: In this descriptive study, antifungal activity of aqueous, ethnolic and methanolic extracts of C. melo fruits were tested on C. albicans; also results were obtained by disc and well diffusion methods. Results: Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of mature C. melo fruit methanolic extract were 25 × 10 3 and 5 × 10 4 μg/mL, respectively. MIC and MFC of immature fruit methanolic extract was 25 × 10 3 . For mature fruit ethanolic extract, MIC and MFC was 25 × 10 3 μg/mL and for immature C. melo fruit ethanolic extract MIC was 25 × 10 3 and MFC was 5 × 10 4 μg/mL. Gas chromatography/mass spectrometry (GC/MS) results showed that hexadecanoic acid was present in all of the extracts. The maximum size of inhibition zone for mature and immature methanolic extact in the disc method was 12 mm and in well method were 15 and 17 mm, respectively. In the disc method, for mature and immature ethanolic extracts maximum size of inhibition zones were 35 and 36 mm and in the well method, maximum size of inhibition zones for mature and immature ethanolic extracts were 28 and 15 mm, respectively. Conclusions: These results indicated that C. melo extracts contain compounds with therapeutic potential and anti-fungal characteristics against C. albicans.

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“…In addition, a recent study on six natural commodities and four commercial medicines against C. albicans revealed that Mayaca extracts could act as a potential antifungal agent for oral thrush caused by C. albicans (Reena et al, 2013). Furthermore, extracts of Althaea officinalis and Matricaria recutita and Combretum molle, Piper capense, Solanum aculeastrum, Syzygium cordatum and Zanthoxylum davyi have a fungicidal effect on C. albicans (Steenkamp et al, 2007;Shakib et al, 2013). However, a study on essential oils and ethanolic extracts from the leaves and roots of 35 medicinal plants commonly used in Brazil, were tested for an antifungal effect on C. albicans and essential oils from 13 plants showed antifungal activity, including Aloysia triphylla, Anthemis nobilis, Cymbopogon martini, Cymbopogon winterianus, Cyperus articulatus, Cyperus rotundus, Lippia alba, Mentha arvensis, Mikania glomerata, Mentha piperita, Mentha sp., Stachys byzantina and Solidago chilensis.…”

Section: Desscusionmentioning

confidence: 99%

ANTIFUNGAL EFFECT OF ETHANOL PLANT EXTRACT ON CANDIDA SP

Al-Judaibi¹

2014

American Journal of Agricultural and Biological Sciences

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In this study, we investigated the in-vitro antimicrobial activity of some medicinal plants in the Arabian peninsula, including Rhamnus globosa, Ocimum basilicum, Tecoma stans and Coleus forskohlii. Our results showed high inhibitory growth in yeast after treatment with R. globosa and O. basilicum. C. tropicalis was shown to be a sensitive strain with an inhibition of 29, 28, 35, 25 and 27 mm after treatment with R. globosa, R. globosa* "leaf with thorns," O. basilicum, Tecoma stans and Coleus forskohlii, respectively. Thus, our results confirmed the fungicidal effect of O. basilicum and R. globosa with a 20 and 30% reduction in CFU compared with the starting inoculums in the time-kill.

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Screening of Venda medicinal plants for antifungal activity against Candida albicans

Cited by 58 publications

References 15 publications

Chemical composition profiling and antifungal activity of the essential oil and plant extracts of <i>Mesembryanthemum edule</i> (L.) bolus leaves

Chemical composition profiling and antifungal activity of the essential oil and plant extracts of <i>Mesembryanthemum edule</i> (L.) bolus leaves

In vitro Antifungal Activity of Cucumis melo on Candida albicans

ANTIFUNGAL EFFECT OF ETHANOL PLANT EXTRACT ON <i>CANDIDA</i> SP

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