Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (<i>Danio rerio</i>) Embryo Test and Molecular Docking

Makarova, Katerina; Siudem, Paweł; Zawada, Katarzyna; Kurkowiak, Justyna

doi:10.1089/zeb.2016.1261

Cited by 26 publications

(18 citation statements)

References 29 publications

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“…It was shown that HQ exhibits a higher toxicity compared with BPA in relation to human promyelocytic leukemia (HL-60) and human oral squamous cell carcinoma (HSC-2) cells (Terasaka et al 2005 ). However, zebrafish embryo toxicity test showed that HQ was much less toxic then BPA (Makarova et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of BPA and HQ toxic impacts on human erythrocytes, protective effect mechanism of tannins (Rhus typhina)

Olchowik-Grabarek

Makarova

Mavlyanov

et al. 2017

Environ Sci Pollut Res

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Several studies reported that bisphenol A (BPA) and its metabolite hydroquinone (HQ) have adverse effects on human and animal health. In this work, a comparative study of influence of the BPA and HQ, environment pollutants, on human erythrocytes was carried out. It was shown that BPA and HQ to varying extents caused oxidative damage in human erythrocytes: hemolysis, decreased GSH level, and methemoglobin formation. It was demonstrated that hydrolysable tannins 3,6-bis-O-di-O-galloyl-1,2,4-tri-O-galloyl-β-d-glucose (C55H40O34) and 1,2,3,4,6-penta-O-galloyl-β-d-glucose (C41H32O26) (PGG) isolated from the Rhus typhina L. leaves in the range of 1–50 μM concentrations inhibited hemolysis and methemoglobin formation and also increased intracellular reduced glutathione in erythrocytes treated with BPA or HQ. It was revealed by electron paramagnetic resonance (EPR) using 5-doxyl-stearic acid (5-DS) that C55H40O34 and C41H32O26 increased the rigidity of erythrocyte membranes at the depth of 5th carbon atom of the fatty acid hydrocarbon chain. Taken together, these results allow to conclude that tannins from the Rhus typhina L. leaves protect erythrocytes from oxidative stress caused by BPA or HQ both due to their antioxidant activity as well as their interaction with the erythrocyte membrane components.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of BPA and HQ toxic impacts on human erythrocytes, protective effect mechanism of tannins (Rhus typhina)

Olchowik-Grabarek

Makarova

Mavlyanov

et al. 2017

Environ Sci Pollut Res

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“…Most recently, zebrafish have been used to study the toxic effects of BPA and the products of its degradation (Makarova, Siudem, Zawada, & Kurkowiak, 2016). The degradation products of BPA were found to have lower binding affinity for both human and zebrafish estrogen receptors than BPA itself but one degradation product, 4-isopopylphenol, was predicted to have a higher binding affinity for the human ERRγ and slightly lower affinity for zebrafish ERRγA.…”

Section: Pathways and Mechanisms Of Toxicant-induced Diseasementioning

confidence: 99%

Zebrafish in Toxicology and Environmental Health

Bambino

Chu

2017

Current Topics in Developmental Biology

307

152

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As manufacturing processes and development of new synthetic compounds increase to keep pace with the expanding global demand, environmental health, and the effects of toxicant exposure are emerging as critical public health concerns. Additionally, chemicals that naturally occur in the environment, such as metals, have profound effects on human and animal health. Many of these compounds are in the news: lead, arsenic, and endocrine disruptors such as bisphenol A have all been widely publicized as causing disease or damage to humans and wildlife in recent years. Despite the widespread appreciation that environmental toxins can be harmful, there is limited understanding of how many toxins cause disease. Zebrafish are at the forefront of toxicology research; this system has been widely used as a tool to detect toxins in water samples and to investigate the mechanisms of action of environmental toxins and their related diseases. The benefits of zebrafish for studying vertebrate development are equally useful for studying teratogens. Here, we review how zebrafish are being used both to detect the presence of some toxins as well as to identify how environmental exposures affect human health and disease. We focus on areas where zebrafish have been most effectively used in ecotoxicology and in environmental health, including investigation of exposures to endocrine disruptors, industrial waste byproducts, and arsenic.

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“…A relatively newer discipline, and highly hot topic, which has become increasingly important in recent years, is the computer-aided in silico toxicity prediction of drugs, food additives, or various industrial chemicals for which a previous wet-lab toxicity outcome is available. For this purpose, QSAR, the CAESAR project, and other virtual screening methods such as docking (i.e., AutoDock, Surflex) software have found wide use in the last decade [82][83][84]. While these software use special parameters (e.g., genetic algorithms), the details of these parameters do not fall into the scope of the main subject of this review article.…”

Section: In Silico Prediction Of Chemical Toxicitymentioning

confidence: 99%

Cell Division, Cytotoxicity, and the Assays Used in the Detection of Cytotoxicity

İstifli¹,

Hüsunet²,

İla³

2019

Cytotoxicity - Definition, Identification, and Cytotoxic Compounds

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Cell division is a phenomenon that is encountered in all cells in nature. While normal cell division results in proliferation in single-celled organisms, and development and repair in multicellular organisms, aberrant and untimely cell division results in tumor formation. Therefore, the understanding of the cell division is hidden in identifying the details of the molecular mechanisms that govern cellular division at the exact time and under right conditions. Sometimes these molecular mechanisms are distorted by both intrinsic and extracellular factors, and the division process halts or deviates to an abnormal pathway. At this point, it is essential that the abnormal cells are removed from the tissue by an appropriate mechanism. In this context, in this review, general and specific information about cell division and its molecular control mechanisms were discussed, and different types of cell death mechanisms were mentioned accordingly. In addition, chemical, biological, and physical cytotoxic agents that negatively affect cell division and their mechanisms of action are explained. Finally, a brief review of the principles of different cytotoxicity (cell viability and proliferation) test systems has been performed to provide a source of information for investigators who study cell viability, proliferation, or different types of cellular death pathways.

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Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking

Cited by 26 publications

References 29 publications

Comparative analysis of BPA and HQ toxic impacts on human erythrocytes, protective effect mechanism of tannins (Rhus typhina)

Comparative analysis of BPA and HQ toxic impacts on human erythrocytes, protective effect mechanism of tannins (Rhus typhina)

Zebrafish in Toxicology and Environmental Health

Cell Division, Cytotoxicity, and the Assays Used in the Detection of Cytotoxicity

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