Screening of some Iranian medicinal plants for anti-tuberculosis, anti-bacterial, and cytotoxic activities

kashi, Marziyeh Esmaeilzadeh; Soheili, Vahid; Asili, Javad; Davoodi, Javid; Soleimanpour, Saman; Karimi, Gholamreza; Taghizadeh, Seyedeh Faezeh; Rezaee, Ramin; Shakeri, Abolfazl

doi:10.1016/j.sajb.2023.01.036

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…R. lutea , Z. clinopodioides ., E. serpens , H. calycinus , and C. lineatus are used as antimicrobials by local people. Additionally, the antimicrobial activity of some other plant species in this study has demonstrated, N. sintenisii [ 12 ], S. lavandulifolia [ 13 ], S. pinnatifida [ 14 ], V. tricolor L. [ 15 ], H. helianthemoides [ 16 ], H. scabrum [ 17 ], G. triphylla [ 18 ], and Z. jujuba [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

Hamidi,

Toosi,

Javadi

et al. 2024

BMC Complement Med Ther

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Background Natural products are one of the best candidates for controlling drug-resistant pathogens, the advantages of which include low production costs and low side effects. In this study, as potential antimicrobials, the anti-bacterial and antibiofilm activities of several Iranian native medicinal plants were screened. Methods The antibacterial/antifungal and anti-biofilm activities of 18 medicinal plants including Reseda lutea L., Nepeta sintenisii Bunge., Stachys turcomanica Trautv., Stachys lavandulifolia Vahl, Diarthron antoninae (Pobed.) Kit Tan., Ziziphora clinopodioides Lam., Euphorbia kopetdaghi Prokh, Euphorbia serpens Kunth., Hymenocrater calycinus Benth., Scutellaria pinnatifida A.Ham., Viola tricolor L., Hypericum helianthemoides (Spach) Boiss., Hypericum scabrum L., Convolvulus lineatus L., Scabiosa rotata M.Bieb Greuter & Burdet, Delphinium semibarbatum Bien. Ex Boiss., Glycyrrhiza triphylla Fisch. & C.A.Mey., and Ziziphus jujuba Mill., against two Gram-positive bacteria, Staphylococcus aureus, Bacillus cereus, as well as two Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli; and Candida albicans as a fungal strain, were evaluated. The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values of the extracts against tested microorganisms were reported and we investigated their effect on the biofilm inhibition of Pseudomonas aeruginosa PAO1, Staphylococcus epidermis, Staphylococcus aureus and Streptococcus mutans. In addition, the effect of the extracts on the eradication of the biofilms of these bacteria was evaluated. Results In this study, H. scabrum was found to exhibit potentially significant activity against Gram-positive bacteria with the MIC range of 6.25–25 µg/mL. This extract also showed a significant effect on inhibiting the biofilm of S. aureus, S. mutans, and S. epidermidis and eradicating the biofilm of S. epidermidis DSMZ 3270. In addition, Hymenocrater calycinus root extract had moderate antibacterial activity against B. cereus with the MIC and MBC 62.5 µg/mL, respectively. Conclusions The results of this study showed that the root extracts of two plants, Hypericum scabrum and Hymenocrater calycinus, had antimicrobial and anti-biofilm effects. Based on the observed anti-biofilm effects, these two plants may be considered in future studies to find responsible antimicrobial compounds.

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Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

Hamidi,

Toosi,

Javadi

et al. 2024

BMC Complement Med Ther

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Chemical profiling and computational identification of potential antibacterials from Adenostemma species

Nurlela,

Wahyudi,

Ilmiawati

et al. 2023

South African Journal of Botany

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Examining the Effect of Hydroalcoholic Extract of Dracaena cinnabari on Sex Hormones and Ovarian and Uterine Tissues of Rats

Najafi,

Hoolari,

Karimi

et al. 2024

World Journal of Traditional Chinese Medicine

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Introduction: Dracaena cinnabari is considered a rich source of phytochemicals used widely in traditional medicine. In the present study, the effect of D. cinnabari hydraulic extract on the reproductive system of female rats was investigated. Methods: The samples were randomly divided into four groups (six samples in each group), including three treatment groups and one control group, and all samples were kept at the same conditions. Hydraulic extract of D. cinnabari and injected intraperitoneally daily for 10 days, while physiological serum was used for injection in to the control group. After 10 days of injection, estrogen and progesterone levels were measured by enzyme immunoassay technique. After dissection, the ovaries and uterine tissues were isolated for histological examination, and tissue changes were carefully examined. Results: The results revealed that the levels of estrogen and progesterone in experimental Groups 2 and 3 had a significant increase (P < 0.001). Regarding tissue changes, a significant increase was observed in epithelial thickness (P < 0.001), number of corpus luteum (P < 0.01), and Graafian follicle (P < 0.01) in doses of 100 and 150 mg/kg. Conclusions: Based on the results, it seems that D. cinnabari extract has an effect on the ovarian follicles.

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Screening of some Iranian medicinal plants for anti-tuberculosis, anti-bacterial, and cytotoxic activities

Cited by 3 publications

References 24 publications

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

Chemical profiling and computational identification of potential antibacterials from Adenostemma species

Examining the Effect of Hydroalcoholic Extract of Dracaena cinnabari on Sex Hormones and Ovarian and Uterine Tissues of Rats

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