Screening of selected essential oils for their in vitro antileishmanial activity against Leishmania amazonensis

Crotti, Antonio E. M.; Santos, Fab; Magalhães, Lizandra Guidi; Wakabayashi, Kamila A. L.; Aguiar, Gabriela P.; Carvalho, Chrislanne Barreira de Macêdo; Melo, Naama Jessica de Assis; Veneziani, Rodrigo Cássio Sola; Albuquerque, Suênia da Cunha Gonçalves de; Filho, Alonso da Silva Lira

doi:10.1055/s-0030-1264751

Cited by 3 publications

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“…As part of our ongoing project on the anti-parasitary activity of essential oils [ 10 ], we report herein the in vitro schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae), an annual aromatic weed from Southeastern Brazil. This species is commonly found in tropical and subtropical zones and is popularly known as “mentrasto” in Portuguese [ 11 , 12 ].…”

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confidence: 99%

Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

et al. 2011

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The in vitro schistosomicidal effects of the essential oil of Ageratum conyzoides L. (Ac-EO) against adult worms of Schistosoma mansoni is reported in this paper. Concerning this activity, Ac-EO was considered to be active, but less effective than the positive control (praziquantel, PZQ) in terms of separation of coupled pairs, mortality, decrease in motor activity, and tegumental alterations. However, Ac-EO caused an interesting dose-dependent reduction in the number of eggs of S. mansoni. Precocene I (74.30%) and (E)-caryophyllene (14.23%) were identified as the two major constituents of Ac-EO. These compounds were tested individually and were found to be much less effective than Ac-EO and PZQ. A mixture of the two major compounds in a ratio similar to that found in the Ac-EO was also less effective than Ac-EO, thus revealing that there are no synergistic effects between these components. These results suggest that the essential oil of A. conyzoides is very promising for the development of new schistosomicidal agents.

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Section: Introductionmentioning

confidence: 99%

Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

et al. 2011

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“…Pharmaceutical research on natural products represents a major opportunity for discovering and developing new drugs and plant-based remedies [2]. Medicinal plants and essential oils already demonstrated antileishmanial activity [3][4][5]. Among the popular plants used for the treatment of leishmaniasis, the aerial parts from Porophyllum ruderale (Jacq.)…”

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Antileishmanial Activity of 5-Methyl-2,2′ : 5′,2″-terthiophene Isolated from Porophyllum ruderale is Related to Mitochondrial Dysfunction in Leishmania amazonensis

et al. 2013

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Recently, our group isolated and reported the antiproliferative activity in promastigotes and axenic amastigote forms of Leishmania amazonensis treated with 5-methyl-2,2':5',2″-terthiophene (compound A) and 5'-methyl-[5-(4-acetoxy-1-butynyl)]-2,2'-bi-thiophene (compound B) isolated from the aerial parts of Porophyllum ruderale. Here, we demonstrated that both compounds exhibited activity against intracellular amastigotes showing IC50 values of 37 and 51 µg/mL for compounds A and B, respectively. Both compounds showed low levels of toxicity for human cells, even at the highest concentrations (hemolytic index < 10 % at 500 µg/mL). Promastigotes treated with compound A showed an alteration in the mitochondrial membrane when observed by flow cytometry through labeling with rhodamine 123 and this was confirmed by transmission electron microscopy. Alterations on morphology (rounded cells) were observed by scanning electron microscopy in parasites treated with the compounds. Further studies should be performed employing compounds A and B for the development of new drugs for chemotherapy of leishmaniasis.

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Antiparasitic Asian medicinal plants in the Clade Campanulids

Wiart¹

2021

Medicinal Plants in Asia and Pacific for Parasitic Infections

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Screening of selected essential oils for their in vitro antileishmanial activity against Leishmania amazonensis

Cited by 3 publications

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Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

Antileishmanial Activity of 5-Methyl-2,2′ : 5′,2″-terthiophene Isolated from Porophyllum ruderale is Related to Mitochondrial Dysfunction in Leishmania amazonensis

Antiparasitic Asian medicinal plants in the Clade Campanulids

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