Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity

Adsersen, Anne; Gauguin, Bente; Gudiksen, Lene; Jäger, Anna K.

doi:10.1016/j.jep.2005.09.032

Cited by 168 publications

(101 citation statements)

References 23 publications

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“…Indeed, increasing the level of acetylcholine (ACh) in the brain may be an effective therapy for AD treatment. Consistently, one of the important treatments for AD is inhibition of AChE, an enzyme responsible for the hydrolysis of Ach and promotes Aβ formation [19,28] . Effective inhibitory action of lavender extract on AChE has been demonstrated [19,29] .…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that aqueous extract of lavender reduces glutamate-induced neurotoxicity [19] . Hence, suppression of glutamatergic neurotoxicity may be also responsible for the alleviation of the cognitive defi cits in AD by the herbal medicine.…”

Section: Discussionmentioning

confidence: 99%

“…Lavender extracts display antioxidant [18] and acetylcholinesterase (AChE) activities [19] . Lavender is also reported to be an effective medical plant in treating infl ammation, depression, stress and headache [17,20] .…”

Section: Introductionmentioning

confidence: 99%

“…Aromatherapy using lavender for agitation intervation is an aspect of dementia treatment [21] . Inhibitory effects of lavender on glutamate-induced neurotoxicity have been reported [19] .…”

Section: Introductionmentioning

confidence: 99%

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Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer’s disease

Kashani¹,

Rezaei‐Tavirani²,

Talaei

et al. 2011

Neurosci. Bull.

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Objective Alzheimer's disease (AD) is one of the most important neurodegenerative disorders. It is characterized by dementia including defi cits in learning and memory. The present study aimed to evaluate the effects of aqueous extract of lavender (Lavandula angustifolia) on spatial performance of AD rats. Methods Male Wistar rats were fi rst divided into control and AD groups. Rat model of AD was established by intracerebroventricular injection of 10 g A1-42 20 d prior to administration of the lavender extract. Rats in both groups were then introduced to 2 stages of task learning (with an interval of 20 d) in Morris water maze, each followed by one probe test. After the fi rst stage of spatial learning, control and AD animals received different doses (50, 100 and 200 mg/kg) of the lavender extract. Results In the fi rst stage of experiment, the latency to locate the hidden platform in AD group was signifi cantly higher than that in control group. However, in the second stage of experiment, control and AD rats that received distilled water (vehicle) showed similar performance, indicating that the maze navigation itself could improve the spatial learning of AD animals. Besides, in the second stage of experiment, control and AD rats that received lavender extract administration at different doses (50, 100, and 200 mg/ kg) spent less time locating the platform (except for the AD rats with 50 mg/kg extract treatment), as compared with their counterparts with vehicle treatment, respectively. In addition, lavender extract signifi cantly improved the performance of control and AD rats in the probe test, only at the dose of 200 mg/kg, as compared with their counterparts with vehicle treatment. Conclusion The lavender extract can effectively reverse spatial learning defi cits in AD rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Aromatherapy using lavender for agitation intervation is an aspect of dementia treatment [21] . Inhibitory effects of lavender on glutamate-induced neurotoxicity have been reported [19] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer’s disease

Kashani¹,

Rezaei‐Tavirani²,

Talaei

et al. 2011

Neurosci. Bull.

View full text Add to dashboard Cite

show abstract

“…The main compositions of lavender are linalool and linalyle acetate [29,30]. Additionally, lavender extracts inhibits glutamate-induced neurotoxicity and promotes anti-AchE activity enhancing the level of Ach in brain [31,32]. It is reported that lavender is an effective medical plant in treating inflammation, depression, stress and headache [28,33].…”

Section: Introductionmentioning

confidence: 99%

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

Soheili¹,

Tavirani²,

Saifeddine³

2012

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An important marker in neurodegenerative Alzheimer's disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

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Thin‐layer Chromatography of Plants, with Chemical and Biological Detection Methods

Urbain

Simões-Pires

2014

Encyclopedia of Analytical Chemistry

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Thin‐layer chromatography ( TLC ) is a widespread separation technique in the field of plant analysis and offers multiple advantages. This versatile technique can provide useful information about the qualitative or semiquantitative chemical composition of a mixture, thanks to coupling, with the detection and spectroscopic techniques and devices for image treatment. Moreover, it can contribute to the detection of biological activity by combining chromatography with bioassays, such as antimicrobial or enzyme inhibition tests. This procedure, providing simultaneous chromatographic separation and in situ assessment of a given biological activity, is named TLC bioautography. The major advantage of this technique is the ability to locate active substances from a complex mixture without prior sample purification. This avoids time‐consuming and tedious isolation of already‐known or inactive compounds. As this method is simple and cost effective, it is suitable for preliminary rapid screening to detect potential activity, as well as being a useful monitoring tool to track the bioguided isolation of active components. In this chapter, we focus on up‐to‐date TLC bioautographic assays, detail their mechanisms and applications in the field of natural drug discovery, and discuss the recent advances of this method that might appear at first glance to be a trivial approach.

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Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity

Cited by 168 publications

References 23 publications

Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer’s disease

Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer’s disease

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

Thin‐layer Chromatography of Plants, with Chemical and Biological Detection Methods

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