Screening of plants used in Mayan traditional medicine to treat cancer-like symptoms

Caamal-Fuentes, Edgar; Torres-Tapia, Luis W.; Simá-Polanco, Paulino; Peraza‐Sánchez, Sergio R.; Moo-Puc, Rosa

doi:10.1016/j.jep.2011.04.004

Cited by 67 publications

(38 citation statements)

References 45 publications

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“…The data also showed that the tested compounds were most cytotoxic to HeLa cells (LC 50 = 3.66–35.69 μg/mL) when compared with Vero cells (LC 50 = 73.88–129.10 μg/mL) indicating that they are less toxic to normal cells. Our results are in agreement with those of Xu et al [39] who showed the cytotoxicity activity of some cytochalasin compounds isolated from the solid substrate culture of Endothia gyrosa IFB-E023 against the human leukaemia K562 cell line with the IC 50 values varying between 1.5 to 28.3 μM.…”

Section: Resultssupporting

confidence: 93%

Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut

Jouda

Tamokou

Mbazoa

et al. 2016

BMC Complement Altern Med

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BackgroundThe continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. We report here the isolation and structure elucidation of antibacterial and cytotoxic compounds from Phomopsis sp., an endophytic fungus associated with Garcinia kola nuts.MethodsThe fungus Phomopsis sp. was isolated from the nut of Garcinia kola. The crude extract was prepared from mycelium of Phomopsis sp. by maceration in ethyl acetate and sequentially fractionated by column chromatography. The structures of isolated compounds were elucidated on the basis of spectral studies and comparison with published data. The isolated compounds were evaluated for their antibacterial and anticancer properties by broth microdilution and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods respectively. The samples were also tested spectrophotometrically for their hemolytic properties against human red blood cells.ResultsThe fractionation of the crude extract afforded three known cytochalasins including 18-metoxycytochalasin J (1), cytochalasins H (2) and J (3) together with alternariol (4). The cytochalasin compounds showed different degrees of antibacterial activities against the tested bacterial pathogens. Shigella flexneri was the most sensitive microorganism while Vibrio cholerae SG24 and Vibrio cholerae PC2 were the most resistant. Ampicillin did not show any antibacterial activity against Vibrio cholerae NB2, Vibrio cholerae PC2 and Shigella flexneri at concentrations up to 512 μg/mL, but interestingly, these multi-drug resistant bacterial strains were sensitive to the cytochalasin metabolites. These compounds also showed significant cytotoxic properties against human cancer cells (LC50 = 3.66–35.69 μg/mL) with low toxicity to normal non-cancer cells.ConclusionThe three cytochalasin compounds isolated from the Phomopsis sp. crude extract could be a clinically useful alternative for the treatment of cervical cancer and severe infections caused by MDR Shigella and Vibrio cholerae.

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Section: Resultssupporting

confidence: 93%

Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut

Jouda

Tamokou

Mbazoa

et al. 2016

BMC Complement Altern Med

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“…In addition, S. jamaicensis was also demonstrated to have antityphoid activity [41] and anti-HIV1 reverse transcriptase inhibitory activity [42], as well as to treat cancer-like symptoms [43]. …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Liew

Yong

2016

Evidence-Based Complementary and Alternative Medicine

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Introduction. Stachytarpheta jamaicensis (L.) Vahl belongs to the family of Verbenaceae and is commonly known as Gervao, Brazilian tea, verbena cimarrona, rooter comb, or blue porter weed. It is one of the important plants with high medicinal and nutraceutical benefits. S. jamaicensis contains various medicinal properties in traditional and folk medicinal systems, with cures for several diseases. Objective. The objective of this review paper is to collect information concerning the morphology, distribution, traditional usage, phytochemical compositions, biological activities, and safety data of S. jamaicensis. Materials and Methods. The information was obtained from literature search through electronic databases such as PubMed and Google Scholar on S. jamaicensis. Results and Conclusion. The high medicinal properties of this plant, for instance, antimicrobial and antifungal effect as the main activities, but verbascoside as the main active chemical component, make it a valuable source of the medicinal compound. This review paper summarizes all information concerning the morphology, distribution, traditional usage, phytochemical compositions, pharmacological activities, and toxicological studies of S. jamaicensis.

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“…Also this extracts can use in treatment leukemia and sickle cell disorder [6]- [8]. Also The studies showed the extracts of the different plants can be use to treat cancer-like symptoms [9]. The studies show these fractions affected proliferation of murine ES, and human embryonal, prostate, and breast carcinoma cells in a dose-dependent manner.…”

Section: Introductionmentioning

confidence: 94%

The Effects of Scrophularia striata Extract on HEK Cell Line in Cell Culture

2016

2016 International Conference on Biological and Environmental Science (BIOES-16) June 8-9, 2016 New Jersey (USA)

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Screening of plants used in Mayan traditional medicine to treat cancer-like symptoms

Cited by 67 publications

References 45 publications

Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut

Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

The Effects of Scrophularia striata Extract on HEK Cell Line in Cell Culture

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