Screening of Organ-Specific Autoantibodies in a Large Cohort of Patients with Autoimmune Thyroid Diseases

Pilli, Tania; Dalmazio, Gilda; Porcelli, Brunetta; Cantara, Silvia; Tabucchi, Antonella; Pini, Alessandro; Spreafico, Adriano; Cartocci, Alessandra; Forleo, Raffaella; Pacini, Furio; Scapellato, Carlo; Castagna, Maria Grazia

doi:10.1089/thy.2021.0170

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…However, Pilia et al ( 7 ), found no significant difference in rates of GAD AAb positivity. Several studies analyzed GAD autoimmunity in adult patients with AT ( 10 , 11 , 14 , 15 , 16 , 19 ) and GD ( 12 , 13 , 15 , 16 ). Relative frequencies of GAD AAb ranged from 2.8-6.6% ( 10 , 11 , 14 , 15 , 16 , 19 ) in patients with AT.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies analyzed GAD autoimmunity in adult patients with AT ( 10 , 11 , 14 , 15 , 16 , 19 ) and GD ( 12 , 13 , 15 , 16 ). Relative frequencies of GAD AAb ranged from 2.8-6.6% ( 10 , 11 , 14 , 15 , 16 , 19 ) in patients with AT. Although a correlation between GAD AAb and AT was found in some studies ( 15 ), it was not always significant ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…One study was performed in children with AT and GD ( 6 ) and three others in children with AT ( 7 , 8 , 9 ). Among studies conducted in adults, some were exclusively carried out in patients with AT ( 10 , 11 ) or GD ( 12 , 13 ), while others included patients with both conditions ( 14 , 15 , 16 , 17 , 18 , 19 ). Islet autoimmunity was assessed by measuring different diabetes-associated AAb as serological markers of β-cell autoimmunity, which included glutamic acid decarboxylase (GAD), islet cell cytoplasmic AAb (ICA), tyrosine-phosphatase (IA2), insulin (IAA), proinsulin and zinc-transporter 8 AAb.…”

Section: Introductionmentioning

confidence: 99%

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Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

Putarek¹,

Krnić²,

Knežević-Ćuća³

et al. 2023

Jcrpe

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Objective: The aim of the present study was to investigate islet autoimmunity and susceptibility to type 1 diabetes (T1D) in children/adolescents with autoimmune thyroid disease (AITD, and in family members of AITD patients with islet autoimmunity. Methods: Islet-cell cytoplasmic, glutamic-acid decarboxylase, and tyrosine-phosphatase autoantibodies (AAbs) were measured in 161 AITD patients [127 with autoimmune thyroiditis (AT); 34 with Graves’ disease (GD)], 20 family members of AITD patients with islet autoimmunity, and 155 age-matched controls. Results: Islet autoimmunity was found in 10.6% of AITD patients, significantly more frequent than in controls (1.9%; p=0.002). A higher prevalence of islet AAbs was found in females with AITD (p=0.011) but not in males (p=0.16) and in AT (p=0.013) but not in GD patients (p=0.19), compared to corresponding controls. Two or three islet AAbs were found concurrently in six AITD patients with islet autoimmunity. They all developed T1D and had significantly higher islet AAbs titers (p=0.01) than AITD patients with single islet AAbs but normal glucose metabolism. T1D was found in 3.7% of AITD patients compared to 0.2% of the age-matched, general Croatian population. Islet AAbs were found in 5/20 family members of AITD patients with islet autoimmunity, among whom two developed T1D. None of the controls was positive for more than one islet AAb or developed T1D. Conclusion: Children/adolescents with AITD, particularly females and patients with AT, appear to represent a risk group for islet autoimmunity and T1D, as do family members of AITD patients with positive islet AAbs. However, these findings should be validated in larger studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

Putarek¹,

Krnić²,

Knežević-Ćuća³

et al. 2023

Jcrpe

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La tiroidite di Hashimoto: meglio sola che male accompagnata

Stramazzo

Centanni

2022

L'Endocrinologo

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A Graves' Disease Patient Diagnosed as Autoimmune Gastritis with Helicobacter pylori Infection

Ahn¹,

Hwang²

2022

Korean J Helicobacter Up Gastrointest Res

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Autoimmune gastritis (AIG) is a type of atrophic gastritis characterized by destruction of parietal cells in the gastric fundus and body. These changes may be attributable to immune-mediated chronic inflammatory responses. AIG is characterized by extensive atrophy of the gastric body; therefore, endoscopic findings offer useful diagnostic clues. AIG is diagnosed based on serological and histopathological evaluation of endoscopic biopsy specimens; however, this condition may be accompanied by autoimmune diseases including autoimmune thyroid disease (ATD), and the opposite can be suspected. Diagnostic delays and misdiagnosis are common in patients with AIG owing to the nonspecific clinical presentation and accompanying autoimmune diseases. Additionally, confirmation of AIG based on serological atrophy or endoscopic findings is challenging in cases of active Helicobacter pylori (H. pylori) infection. We report a case of Graves’ disease (an ATD) in a patient diagnosed with AIG and concomitant H. pylori-induced gastritis based on the rapid urease and serological test results and endoscopic biopsy findings.

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Screening of Organ-Specific Autoantibodies in a Large Cohort of Patients with Autoimmune Thyroid Diseases

Cited by 3 publications

References 49 publications

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

La tiroidite di Hashimoto: meglio sola che male accompagnata

A Graves' Disease Patient Diagnosed as Autoimmune Gastritis with Helicobacter pylori Infection

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Screening of Organ-Specific Autoantibodies in a Large Cohort of Patients with Autoimmune Thyroid Diseases

Cited by 3 publications

References 49 publications

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

La tiroidite di Hashimoto: meglio sola che male accompagnata

A Graves&apos; Disease Patient Diagnosed as Autoimmune Gastritis with Helicobacter pylori Infection

Contact Info

Product

Resources

About

A Graves' Disease Patient Diagnosed as Autoimmune Gastritis with Helicobacter pylori Infection