Screening of Natural Herb Resources for Anti-oxidative Effects in Korea

Yang, Yoon-Jung; Kim, Hyun-Jun; Kang, Shin-Ho; Kang, Se‐Chan

doi:10.7732/kjpr.2011.24.1.001

Cited by 19 publications

(7 citation statements)

References 7 publications

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“…한편, 대부분의 호기성 생물은 각종 스 트레스를 받으면 산소분자의 감소는 superoxide anion radicals, singlet oxygen, hydrogen peroxide, hydroxyl peroxide, hydroxyl radical과 같은 독성이 높은 활성산 소종(reactive oxigen species, ROS)을 생성시키며 (Allen, 1995), 생물들은 이런 독성으로부터 자신을 보호하기 위하 여 방어물질인 ascorbate peroxidase(APX), superoxide dismutase(SOD), catalase(CAT), peroxidase(POD) 등 의 항산화 효소와 ascorbic acid, glut achion, caroteno id 등의 항산화 물질을 생성시킨다 (Jeong, 2001;Yang et al, 2011). 이러한 항산화 효소들은 세포막의 지질 과산화 손상, sulfhydryl-함유 효소의 불활성화, 구성 단백질의 교차결합 등을 일으키는 활성산소종을 불활성화 시키거나 제거함으로서 항산화 작용을 하게 된다 (Bradford, 1976).…”

Section: Al 2011) 이와 같이 대청의 약리적 효능에 대해서는 많 은 연구가 이루어졌지만 세포내 지질의 과unclassified

Antioxidant Enzyme Activity and Antimicrobial Activity of Isatis tinctoria Extract

Heo¹,

Park²,

Lee³

et al. 2012

Korean Journal of Plant Resources

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-To gather the basic data for increasing the utilization of Isatis tinctoria, we examined the effects of both antioxidative enzyme activity and antimicrobial activity from the extract of Isatis tinctoria. Ascorbate Peroxidase activities reveal that there is an decrease in order; ethanol extract from its stem (1601.7 Unit/ mg protein), methanol extract from its leaf (1133.7 Unit/ mg protein) and distilled water extract from its leaf (524.3 Unit/ mg protein). Catalase activities reveal that there is an decrease in order; ethanol extract from its flower petal (177.1 Unit/ mg protein), methanol extract from its leaf (120.8 Unit/ mg protein) and distilled water extract from its flower petal (55.4 Unit/ mg protein). Peroxidase activities reveal that there is an decrease in order; ethanol extract from its flower petal (27.1 Unit/ mg protein), methanol extract from its flower petal (14.6 Unit/ mg protein) and distilled water extract from its stem (10.4 Unit/ mg protein). Superoxide dismutase activities reveal that there is an increase in order; distilled water extract from its root (90.8%), methanol extract from its flower petal (80.1%) and ethanol extract from its root (75.5%). Its flower extract showed a antimicrobial activity only against Vibrio parahaemolyticus, its root extract had only against Staphylococcus aureus, and its stem extract had against Bacillus subtilis, Escherichia coli and Staphylococcus aureus, regardless of solvents. Especially, distilled water extract from its leaf showed a high antimicrobial activity against both Bacillus subtilis and Escherichia coli and inhibition diameters against those were 30.0 and 24.0 mm, respectively.

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Section: Al 2011) 이와 같이 대청의 약리적 효능에 대해서는 많 은 연구가 이루어졌지만 세포내 지질의 과unclassified

Antioxidant Enzyme Activity and Antimicrobial Activity of Isatis tinctoria Extract

Heo¹,

Park²,

Lee³

et al. 2012

Korean Journal of Plant Resources

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“…최근 약용작물의 2차 대사산물들이 생체에서 나타 내는 생리활성들에 대한 연구가 활발히 진행되고 있고 [18,23,34], 약용식물자원에서 항알레르기, 항산화, 항균 및 항 생활습관병 등의 약리성 물질 탐색과 이들 유용성분을 이용하 려는 연구가 활발하게 진행되고 있다 [3,36].…”

Section: 서 론unclassified

Charactrization of Biological Activities of Rehmannia glutinosa Extracts

Cho¹

2012

Journal of Life Science

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The content phenolic compounds in extracts from Rehmannia glutinosa was the highest in 40% ethanol extracts as 5.1±0.2 mg/g. DPPH scavenging activity of R. glutinosa extracts was high in water extracts and 40% ethanol extracts as 85~93%, ABTS radical cation decolorization of water extracts and 40% ethanol extracts was about the same as 55~62%, antioxidant protection factor (PF) was confirmed in water extracts and 40% ethanol extracts as 1.6~1.9 PF, and TBARs of water extracts and 40% ethanol extracts were concluded to have the similar antioxidant effects. The hypertension inhibitory activity of water extracts and 40% ethanol extracts from R. glutinosa indicated the activities as 87.2% and 81.1%, anti-gout activity was determined very low in R. glutinosa extracts and antimicrobial activity against skin microorgasm was confirmed, and tyrosinase inhibitory activity was determined as 70.2% in 40% ethanol extracts, it was expected the whitening effects in 40% ethanol extracts. The elastase inhibitory activity which are related to the wrinkle cause was observed in water extracts and 40% ethanol extracts as 76.2% and 57.2%. The hyaluronidase inhibitory activity to R. glutinosa extracts was observed weakly in only 40% ethanol extracts of 200 μg/ml phenolic content as 5.1%.

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“…감초와 같은 콩과 식물로 알려진 갈근(Pueraiae radix)은 항 알러지 효과가 보고되어 있으며 (Jeong et al, 2013), 호지라 불 리는 싸리(Lespedeza bicolor Turcz.) 역시 콩과 식물로서 항산 화 효과가 보고되어 있다 (Yang et al, 2011). 감초의 생리 활성 작용으로는 항염, 해독, 항암, 항당뇨, 항혈전, 항궤양, melanin 형성 억제 작용 등이 알려져 있다 (Aarsen, 1973;Tanaka et al, 1991).…”

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Studies on Standardization of Licorice Based on Its Active Components with On-line HPLC Bioassay System

Hong¹,

Kang²,

Jang³

et al. 2014

Korean Journal of Plant Resources

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-In an attempt to evaluate licorice quality based on its biological activity, we grafted an on-line high-performance liquid chromatography (HPLC) bioassay method into the previously established HPLC analysis method. The common antioxidant peaks in licorices of various origin were observed through an on-line HPLC/DPPH system leading to a decrease in absorbance at 517 ㎚ for 2,2-diphenyl-1-picrylhydrazyl (DPPH). Among them, the licorice from Youngju possessed the highest activity. Therefore, three active standard compounds from the dehydroglyasperin C, dehydroglyasperin D, and isoangustone A, were isolated and elucidated by medium pressure liquid chromatography (MPLC) and instrumental analysis such as nuclear magnetic resonance (NMR), respectively. On-line HPLC/ABTS analysis method with the simultaneous determination of three standard compounds and their radical scavenging activity was established for the quality evaluation of licorices. 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radicals (ABTS᠂) which is stable and effective was used in replace of DPPH. The radical scavenging activity of three standards is compared with that of Trolox, known as antioxidant, showing a negative peak with a decrease in absorbance at 734 ㎚ for ABTS. This on-line HPLC/ABTS analysis method was validated for specificity, linearity, precision and accuracy in compliance with international conference on harmonization (ICH) guideline.

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Screening of Natural Herb Resources for Anti-oxidative Effects in Korea

Cited by 19 publications

References 7 publications

Antioxidant Enzyme Activity and Antimicrobial Activity of Isatis tinctoria Extract

Antioxidant Enzyme Activity and Antimicrobial Activity of Isatis tinctoria Extract

Charactrization of Biological Activities of Rehmannia glutinosa Extracts

Studies on Standardization of Licorice Based on Its Active Components with On-line HPLC Bioassay System

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