Screening of metabolites in the treatment of liver cancer xenografts HepG2/ADR by psoralen-loaded lipid nanoparticles

Li, Lihong; Zou, Tengteng; Liang, Min; Mezhuev, Ya. O.; Tsatsakis, Aristidis; Djordjevic, Aleksandra Buha; Lan, Meng; Liu, Fengjie; Cai, Tiange; Gong, Peng; Cai, Yu

doi:10.1016/j.ejpb.2021.05.025

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Minimization of cardiotoxic effects and the implementation of combination therapy are the main goals in using nanosized carriers for doxorubicin immobilization [39]. As carriers of doxorubicin, nanosystems based on boron nitride [40], lipids [41], dextran [42], PLGA [43], polydopamine [44], iron oxide [45], gold [46], collagen and poly(3-acrylamidophenylboronic acid) [47] have been reported in the literature. The reported strategies involve the controlled release of doxorubicin, which has a cumulative dose [48] and limits the available treatment options.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel

et al. 2022

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Co-delivery of chemotherapeutics in cancer treatment has been proven essential for overcoming multidrug resistance and improving the outcome of therapy. We report the synthesis of amphiphilic copolymers of N-vinyl-2-pyrrolidone and allyl glycidyl ether of various compositions and demonstrate that they can form nanoaggregates capable of simultaneous covalent immobilization of doxorubicin by the epoxy groups in the shell and hydrophobic-driven incorporation of paclitaxel into the core of nanoparticles. The structure of the obtained copolymers was characterized by 13C NMR, IR, and MALDI spectroscopy, as well as adsorption at the water/toluene interface. A linear increase in the number-average molecular weight of amphiphilic copolymers and a decrease in the number-average diameter of macromolecular aggregates with an increase in the ratio N-vinyl-2-pyrrolidone/allyl glycidyl ether were observed. The assembled nanocarriers were characterized by DLS. The reported novel nanocarriers can be of interest for delivery and co-delivery of a wide range of pharmacological preparations and combined therapy for cancer and other deceases.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel

et al. 2022

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“…Metabolomics analysis in mouse serum and liver demonstrated that NpRg3 application inhibited HCC progression by increasing free fatty acids, decreasing 3-indolepropionic acid and urea, and remodelling the unbalanced gut microbiota (Ren et al, 2020). Table 3 also summarizes other usages of metabonomics approaches in identifying metabolite changes in response to triterpenoid saponins from Anemone flaccida F. Schmidt (Han et al, 2019), Solasonine isolated from Solanum melongena L. (Jin et al, 2020), psoralen-loaded polymer lipid nanoparticles (Li et al, 2021), Annona squamosa L. (Ma et al, 2019b), and Rhizoma Paridis saponins (Qiu et al, 2016).…”

Section: Metabolomicsmentioning

confidence: 99%

OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives

et al. 2022

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Gastrointestinal cancers refer to a group of deadly malignancies of the gastrointestinal tract and organs of the digestive system. Over the past decades, considerable amounts of medicinal plants have exhibited potent anticancer effects on different types of gastrointestinal cancers. OMICS, systems biology approaches covering genomics, transcriptomics, proteomics and metabolomics, are broadly applied to comprehensively reflect the molecular profiles in mechanistic studies of medicinal plants. Single- and multi-OMICS approaches facilitate the unravelling of signalling interaction networks and key molecular targets of medicinal plants with anti-gastrointestinal cancer potential. Hence, this review summarizes the applications of various OMICS and advanced bioinformatics approaches in examining therapeutic targets, signalling pathways, and the tumour microenvironment in response to anticancer medicinal plants. Advances and prospects in this field are also discussed.

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“…Psoralen packed in polymer lipid nanoparticles (PSO-PLNs) are extensively utilized in drug delivery to increase the solubility and stability of psoralen. To evaluate the beneficial effects of PSO-PLNs against HCC, a LC-MS-based metabolomics analysis was conducted on serum and urine from mice engrafted with HepG2 cells resistant against doxorubicin ( Li et al, 2021 ). In detail, PSO-PLNs had stronger degree of regression of metabolites including α-linolenic acid, retinoic acid, pantothenic acid, hyaluronic acid, and hippuric acid than psoralen.…”

Section: Applications Of Metabolomics For Medicinal Plants In Gastroi...mentioning

confidence: 99%

Medicinal Plants for the Treatment of Gastrointestinal Cancers From the Metabolomics Perspective

et al. 2022

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Gastrointestinal cancer (GIC), primarily including colorectal cancer, gastric cancer, liver cancer, pancreatic cancer, and esophageal cancer, is one of the most common causes of cancer-related deaths with increasing prevalence and poor prognosis. Medicinal plants have been shown to be a great resource for the treatment of GIC. Due to their complex manifestations of multi-component and multi-target, the underlying mechanisms how they function against GIC remain to be completely deciphered. Cell metabolism is of primary importance in the initialization and development of GIC, which is reported to be a potential target. As an essential supplement to the newest “omics” sciences, metabolomics focuses on the systematic study of the small exogenous and endogenous metabolites involved in extensive biochemical metabolic pathways of living system. In good agreement with the systemic perspective of medicinal plants, metabolomics offers a new insight into the efficacy assessment and action mechanism investigation of medicinal plants as adjuvant therapeutics for GIC therapy. In this review, the metabolomics investigations on metabolism-targeting therapies for GIC in the recent 10 years were systematically reviewed from five aspects of carbohydrate, lipid, amino acid, and nucleotide metabolisms, as well as other altered metabolisms (microbial metabolism, inflammation, and oxidation), with particular attention to the potential of active compounds, extracts, and formulae from medicinal plants. Meanwhile, the current perspectives and future challenges of metabolism-targeting therapies of medicinal plants for GIC were also discussed. In conclusion, the understanding of the action mechanisms of medicinal plants in GIC from the metabolomics perspective will contribute to the clinical application of potential candidates from the resourceful medicinal plants as novel and efficient adjuvant therapeutics for GIC therapy.

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Screening of metabolites in the treatment of liver cancer xenografts HepG2/ADR by psoralen-loaded lipid nanoparticles

Cited by 9 publications

References 33 publications

Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel

Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel

OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives

Medicinal Plants for the Treatment of Gastrointestinal Cancers From the Metabolomics Perspective

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