Screening of human and veterinary pharmaceuticals in estuarine waters: A baseline assessment for the Tejo estuary

Patrick, Ruth; Pais, Miguel Pessanha; Duarte, Bernardo; Freitas, Andreia; Pouca, Ana Sofia Vila; Barbosa, Jorge; Leston, Sara; Rosa, João; Ramos, Fernando; Cabral, Henrique N.; Gillanders, Bronwyn M.; Fonseca, Vanessa F.

doi:10.1016/j.marpolbul.2018.08.036

Cited by 76 publications

(29 citation statements)

References 31 publications

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“…Most previous studies, to measure EPs, particularly pharmaceuticals, in inland and coastal waters in South Africa have used a quantitative and targeted approach (Madikizela et al 2017a , Petrik et al 2017 ). In order to simplify the data generated, several workers have proposed different ways to classify the various classes of EPs detected in surface water (Reis-Santos et al 2018 ; Archer et al 2017b ; Naude et al 2015 ). We classified the compounds into six main groups (medicines, psychotropic drugs, metabolites, central nervous system (CNS) stimulants, poisons and food components/additives) and 37 subgroups that describe their major uses (Tables 1 , 2 , 3 , 4 , 5 and 6 ).…”

Section: Resultsmentioning

confidence: 99%

“…However, the presence of a plethora of EPs at low concentrations in heavily contaminated aquatic systems can have a synergistic effect. This can exert pharmacological and metabolic effects capable of altering homeostasis, physiological function and behaviour as well as phenotypic plasticity in aquatic animals (Reis-Santos et al 2018 ; Saaristo et al 2018 ). The impacts of new chemicals, which are continuously being developed and introduced to consumers worldwide, are a growing issue generating considerable interest amid environmental safety concerns (Ebele et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Use of the Chemcatcher® passive sampler and time-of-flight mass spectrometry to screen for emerging pollutants in rivers in Gauteng Province of South Africa

Rimayi¹,

Chimuka

Gravell

et al. 2019

Environ Monit Assess

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Many rivers in urbanised catchments in South Africa are polluted by raw sewage and effluent to an extent that their ecological function has been severely impaired. The Hennops and Jukskei Rivers lying in the Hartbeespoort Dam catchment are two of the worst impacted rivers in South Africa and are in need of rehabilitation. Passive sampling (Chemcatcher® with a HLB receiving phase) together with high-resolution tandem mass spectrometry–targeted screening was used to provide high sensitivity and selectivity for the identification of a wide range of emerging pollutants in these urban waters. Over 200 compounds, including pesticides, pharmaceuticals and personal care products, drugs of abuse and their metabolites were identified. Many substances (~ 180) being detected for the first time in surface water in South Africa. General medicines and psychotropic drugs were the two most frequently detected groups in the catchment. These accounted for 49% of the emerging pollutants found. Of the general medicines, antihypertensive agents, beta-blocking and cardiac drugs were the most abundant (28%) classes detected. The Hennops site, downstream of a dysfunctional wastewater treatment plant, was the most polluted with 123 substances detected. From the compounds detected, peak intensity–based prioritisation was used to identify the five most abundant pollutants, being in the order caffeine > lopinavir > sulfamethoxazole > cotinine > trimethoprim. This work provides the largest available high-quality dataset of emerging pollutants detected in South African urban waters. The data generated in this study provides a solid foundation for subsequent work to further characterise (suspect screening) and quantify (target analysis) these substances. Electronic supplementary material The online version of this article (10.1007/s10661-019-7515-z) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of the Chemcatcher® passive sampler and time-of-flight mass spectrometry to screen for emerging pollutants in rivers in Gauteng Province of South Africa

Rimayi¹,

Chimuka

Gravell

et al. 2019

Environ Monit Assess

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“…Taking in consideration that most WWTPs effluents are discharged into rivers, it is expected that CECs are found in estuarine areas. In fact, several pharmaceutical compounds have been found in Portuguese rivers and estuaries (Madureira et al, 2010;Paíga et al, 2016;Barbosa et al, 2018;Reis-Santos et al, 2018;Sousa et al, 2019) as well as in other parts of the world (Thomas & Hilton, 2004;López-Serna & Petrović, 2012;Yan et al, 2015;Aminot et al, 2016;Cantwell et al, 2018), mainly due to inefficient removal at wastewater treatment plants (WWTPs). Pharmaceutical detected included for instance, carbamazepine, diazepam, fenofibric acid, propranolol, trimethoprim and sulfamethoxazole (Madureira et al, 2010) and fluoxetine, ibuprofen, salicylic acid and ketoprofen (Paíga et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Pharmaceutical detected included for instance, carbamazepine, diazepam, fenofibric acid, propranolol, trimethoprim and sulfamethoxazole (Madureira et al, 2010) and fluoxetine, ibuprofen, salicylic acid and ketoprofen (Paíga et al, 2016). Bezafibrate was also among the pharmaceuticals detected in Portuguese rivers and estuaries (e.g., Barbosa et al, 2018, Reis-Santos et al, 2018.…”

Section: Introductionmentioning

confidence: 99%

Potential of an estuarine salt marsh plant (Phragmites australis (Cav.) Trin. Ex Steud10751) for phytoremediation of bezafibrate and paroxetine

et al. 2020

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This study aimed to evaluate the potential of a salt marsh plant and its rhizosphere microorganisms for the removal of two pharmaceutical compounds, bezafibrate and paroxetine, from estuarine environment. Plants were exposed for 7 days to a simplified estuarine medium, elutriate solution with or without sediment, doped with bezafibrate or paroxetine. Tests were done in absence and presence of nutrients or copper. Phragmites australis (Cav.) Trin. Ex Steud, alone or with the sediment microbial communities, contributed for pharmaceuticals removal. In the presence of P. australis, for paroxetine a 65% removal was observed. Removal increased up to 90% when sediment was present. For bezafibrate, removals reached ca. 47% in P. australis presence, increasing to ca. 70% when nutrients were added to the medium, indicating a good nutritional state can contribute for a higher compound removal. When Cu was added, 75% removal for bezafibrate and 95% removal for paroxetine were observed indicating the metal might influence the removal of the pharmaceuticals. Overall, the plant and its rhizosediments and associated microorganisms showed potential for pharmaceuticals removal from estuaries, eventually degrading the selected compounds, a feature requiring more research. Results indicate that phytoremediation could be a viable option for eliminating/diminishing

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“…So far, a maximum level of 10 ng L −1 for the presence of pharmaceuticals in natural waters was established to avoid environmental and health risks [4]. Ibuprofen is not only the most widely used pharmaceutical compound, but also the most frequently found in natural and drinking water worldwide [2,3,5,6]. According to NORMAN and KNAPPE European projects, which compiled data from 117 studies on the presence of pharmaceuticals and personal care products (PPCPs) in wastewater from Europe, Brazil, and North America, ibuprofen is among the PPCPs with the highest concentrations in effluents [7].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Ibuprofen from Natural Waters Using a Covalent Organic Framework

et al. 2020

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Ibuprofen is one of the most widely used pharmaceuticals, and due to its inefficient removal by conventional wastewater treatment, it can be found in natural surface waters at high concentrations. Recently, we demonstrated that the TpBD-(CF3)2 covalent organic framework (COF) can adsorb ibuprofen from ultrapure water with high efficiency. Here, we investigate the performance of the COF for the extraction of ibuprofen from natural water samples from a lake, river, and estuary. In general, the complexity of the natural water matrix induced a reduction in the adsorption efficiency of ibuprofen as compared to ultrapure water. The best performance, with over 70% adsorption efficiency, was found in lake water, the sample which featured the lowest pH. According to the theoretical calculations, ibuprofen more favorably interacts with the COF pores in the protonated form, which could partially account for the enhanced adsorption efficiency found in lake water. In addition, we explored the effect of the presence of competing pharmaceuticals, namely, acetaminophen and phenobarbital, on the ibuprofen adsorption as binary mixtures. Acetaminophen and phenobarbital were adsorbed by TpBD-(CF3)2 with low efficiency and their presence led to an increase in ibuprofen adsorption in the binary mixtures. Overall, this study demonstrates that TpBD-(CF3)2 is an efficient adsorbent for the extraction of ibuprofen from natural waters as well.

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Screening of human and veterinary pharmaceuticals in estuarine waters: A baseline assessment for the Tejo estuary

Cited by 76 publications

References 31 publications

Use of the Chemcatcher® passive sampler and time-of-flight mass spectrometry to screen for emerging pollutants in rivers in Gauteng Province of South Africa

Use of the Chemcatcher® passive sampler and time-of-flight mass spectrometry to screen for emerging pollutants in rivers in Gauteng Province of South Africa

Potential of an estuarine salt marsh plant (Phragmites australis (Cav.) Trin. Ex Steud10751) for phytoremediation of bezafibrate and paroxetine

Extraction of Ibuprofen from Natural Waters Using a Covalent Organic Framework

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