Abstract:Hepatocellular carcinoma (HCC) is a deadly primary tumour that begins in hepatocytes. Tumour cell proliferation and progression is influenced by cellular components of the liver and their microenvironment. Pharmacodynamic (PD) biomarkers are biomolecules that demonstrate the effect of a therapeutic intervention on the affected organ and its microenvironment. PD biomarkers are used to study drug target interactions and their biological responses. High-throughput technologies and bioinformatics tools are critica… Show more
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