Screening of Health-Associated Oral Bacteria for Anticancer Properties in vitro

Baraniya, Divyashri; Jain, Vinay; Lucarelli, Ronald; Tam, Vincent C.; Vanderveer, Lisa; Puri, Sumant; Yang, Maobin; Al-Hebshi, Nezar N.

doi:10.3389/fcimb.2020.575656

Cited by 31 publications

(29 citation statements)

References 50 publications

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“… 32 In OSCC cell lines, Lautropia mirabilis upregulated IL-6 and TNF-α, which are cytokines related to the inflammatory response. 42 All these genera were verified in LEfSe analysis in the current study.…”

Section: Discussionsupporting

confidence: 66%

Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension

Chen¹,

Chen²,

Feng³

et al. 2022

NSS

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Purpose Microorganisms contribute to the pathogenesis of obstructive sleep apnea (OSA)-associated hypertension (HTN), while more studies focus on intestinal microbiome. However, the relationship between oral microbiota and OSA-associated HTN has yet to be elucidated. This study aimed to identify differences in salivary microbiota between patients with OSA comorbid HTN compared with OSA patients, and furthermore evaluate the relationship between oral microbiome changes and increased blood pressure in patients with OSA. Patients and Methods This study collected salivary samples from 103 participants, including 27 healthy controls, 27 patients with OSA, 23 patients with HTN, and 26 patients with OSA comorbid HTN, to explore alterations of the oral microbiome using 16S rRNA gene V3-V4 high-throughput sequencing. And ultra-high-performance liquid chromatography was used for metabolomic analysis. Results Alpha- and beta-diversity analyses revealed a substantial difference in community structure and diversity in patients with OSA comorbid HTN compared with patients with OSA or HTN. The relative abundance of the genus Actinomyces was significantly decreased in patients with HTN compared with healthy controls, and those with OSA concomitant HTN compared with the patients in OSA, but was not significantly different between patients with OSA and healthy controls. Linear discriminant analysis effect size and variance analysis also indicated that the genera Haemophilus, Neisseria , and Lautropia were enriched in HTN. In addition, Oribacterium was an unique taxa in the OSA comorbid HTN group compared with the control group. Metabolomic analysis of saliva identified compounds associated with cardiovascular disease in patients with OSA comorbid HTN.2-hydroxyadenine, was significantly increased in the group of patients with OSA compared with controls, and L-carnitine was significantly decreased in patients with OSA comorbid HTN compared with OSA patients. Conclusion This study highlighted noninvasive biomarkers for patients with OSA comorbid HTN. As the first study to find alterations of the salivary microbiome in patients with OSA comorbid HTN, it may provide a theoretical foundation for clinical diagnosis and treatment of this condition.

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Section: Discussionsupporting

confidence: 66%

Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension

Chen¹,

Chen²,

Feng³

et al. 2022

NSS

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“…It could be inferred that higher R.Mucilaginosa was always presented in cancer patients. What is more, it is reported R.Mucilaginosa upregulated TNF-α and upregulation of CD36 in all cell lines in cocultures [20] and increased abundance of R.Mucilaginosa exhibited the ability to produce acetaldehyde [21,22]. The above functional could explain the ndings of the present study that higher R.Mucilaginosa in esophageal cancerous tissue than that in para-cancerous.…”

Section: Discussionsupporting

confidence: 59%

Characteristic and Interplay of Esophageal Microbiota in Esophageal Squamous Cell Carcinoma

Lin

Rao

Xiang

et al. 2021

Preprint

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Background: Esophageal squamous cell carcinoma(ESCC) is severe cancer in the world. The role of esophageal microbiota for ESCC is still uncertain. In the current study, 120 paired tissues from ESCC patients were collected, and 16s rRNA sequencing was performed to explore the esophageal microbiota. Results: The present investigation shows that the diversity and composition of the microbiota in ESCC cancerous tissues and para-cancerous tissues is significantly different, this variation between subjects beta diversity mainly explained by regions and sampling seasons. Species R.Mucilaginosa, P.Endodontalis, unclassified species in genus Leptotrichia, genus Phyllobacterium, and genus Sphingomonas were enriched in cancerous tissue. On the other hand, class Bacilli, N.Subflava, H.Pylori, A.Parahaemolyticus, A.Rhizosphaerae, unclassified species in genus Campylobacter and genus Haemophilus were increased in para-cancerous tissue. Compared with the co-occurrence network in cancerous tissue, a denser and more complex association network was formed in para-cancerous tissue. Moreover, the above differential taxa also participated in both co-occurrence network but played quite different roles. Finally, the functional association analyses revealed the altered signaling pathways in ESCCs were correlated to esophageal microbiota. Conclusion: Compared with para-cancerous tissues, microbiota in cancerous tissues showed significant differences in diversity and composition. The alterations in microbial co-occurrence network and functional pathways in ESCC tissues may be involved in carcinogenesis and the maintenance of local microenvironment for ESCC. These discoveries of the esophageal microbiota for ESCC patients may contribute to the etiology for ESCC prevention, diagnosis, early intervention, and treatment.

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“…Mechanisms of association of selected aerobic and anaerobic bacteria with tumors of the oral cavity are presented in Table 1 [ 4 , 9 , 15 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]; an overview of selected bacteria most frequently identified in association with OSCC is provided in Table S1 (Supplementary Materials) [ 12 , 13 , 14 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Oral Bacteria Associated With Oral Cancermentioning

confidence: 99%

“…Thus, it has been proposed as a possible early tumor marker [ 18 ]. On the other hand, Baraniya et al demonstrated the in vitro ability of S. mitis to inhibit OSCC tumor cell proliferation through cytotoxicity mediated by hydrogen peroxide production [ 37 ]. Nevertheless, although such a potential protective action could be attributed to S. mitis , these bacteria are also one of the major producers of carcinogenic acetaldehyde and, moreover, can induce the production of proinflammatory cytokines [ 76 ].…”

Section: Oral Bacteria Associated With Oral Cancermentioning

confidence: 99%

The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma

et al. 2021

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Dysbiosis in the oral environment may play a role in the etiopathogenesis of oral squamous cell carcinoma (OSCC). This review aims to summarize the current knowledge about the association of oral microbiota with OSCC and to describe possible etiopathogenetic mechanisms involved in processes of OSCC development and progression. Association studies included in this review were designed as case–control/case studies, analyzing the bacteriome, mycobiome, and virome from saliva, oral rinses, oral mucosal swabs, or oral mucosal tissue samples (deep and superficial) and comparing the results in healthy individuals to those with OSCC and/or with premalignant lesions. Changes in relative abundances of specific bacteria (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus sp.) and fungi (especially Candida sp.) were associated with OSCC. Viruses can also play a role; while the results of studies investigating the role of human papillomavirus in OSCC development are controversial, Epstein–Barr virus was positively correlated with OSCC. The oral microbiota has been linked to tumorigenesis through a variety of mechanisms, including the stimulation of cell proliferation, tumor invasiveness, angiogenesis, inhibition of cell apoptosis, induction of chronic inflammation, or production of oncometabolites. We also advocate for the necessity of performing a complex analysis of the microbiome in further studies and of standardizing the sampling procedures by establishing guidelines to support future meta-analyses.

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Screening of Health-Associated Oral Bacteria for Anticancer Properties in vitro

Cited by 31 publications

References 50 publications

Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension

Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension

Characteristic and Interplay of Esophageal Microbiota in Esophageal Squamous Cell Carcinoma

The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma

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