Screening of Echinops ellenbeckii and Echinops longisetus for biological activities and chemical constituents

Hymete, Ariaya; Iversen, Tor‐Henning; Rohloff, Jens; Erko, Berhanu

doi:10.1016/j.phymed.2004.01.013

Cited by 46 publications

(43 citation statements)

References 7 publications

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“…Contents of the plates were then incubated in humidified atmosphere at 318 (for L. aethiopica) or at 378 (for L. donovani) under 5% CO 2 for 72 h. After 68 h of incubation, 10 ml of fluorochrome resazurin (Sigma Chemical Co., St. Louis, USA) soln. (12.5 mg dissolved in 100 ml PBS, pH 7.2) was added into each well, and the fluorescence intensity was measured after a total incubation time of 72 h using Victor 3 Multilabel Counter (Perkin-Elmer), at an excitation wavelength of 530 nm and emission wavelength of 590 nm. Assays with standard antileishmanial drugs and medium with 1% DMSO were also performed to have reference values.…”

Section: Experimental Partmentioning

confidence: 99%

Essential‐Oil Composition, Antileishmanial, and Toxicity Study of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia

Tariku

Hymete

Hailu

et al. 2010

Chemistry & Biodiversity

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Essential oils of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia were analyzed by GC and GC/MS, and screened for leishmanicidal activity against promastigote and axenic amastigotes of Leishmania donovani and L. aethiopica, including toxicity studies on human monocytic leukemia cells (THP-1) and erythrocytes in vitro. GC/MS of A. abyssinica oil revealed 67 compounds (99.94%) with the major constituents yomogi alcohol (38.47%), artemisyl acetate (24.88%), and artemisia alcohol (6.70%), and oxygenated monoterpenes (84.00%) as the dominant group. The oil of S. punctata contained 67 compounds (99.49%) with the main constituents geranial (27.62%), neral (21.72%), alpha-bisabolol (13.62%), and (E)-nerolidol (4.82%), of which oxygenated mono- and sesquiterpenes (58.39 and 26.91%, resp.) showed highest abundance. Both oils showed effect on promastigotes (MIC 76.5 to 312.5 nl/ml) and amastigotes (EC(50) 4.06 to 131.00 nl/ml) of L. donovani and L. aethiopica, and varying toxicities on THP-1 cells (CC(50) 0.013 to 350 nl/ml with selectivity index between 0.001 and 28) and erythrocytes (with LC(50) 0.35 to 1.52 microl/ml). S. punctata oil exerted highest activity against both Leishmania sp. and toxicity. The revealed antileishmanial activities support further isolation and investigation of oil constituents for in vitro/in vivo evaluation.

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Section: Experimental Partmentioning

confidence: 99%

Essential‐Oil Composition, Antileishmanial, and Toxicity Study of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia

Tariku

Hymete

Hailu

et al. 2010

Chemistry & Biodiversity

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“…As a result of studies carried out with Echinops from the Asteraceae family up to the present, it has been proven that taxa of the Echinops species are effective against migraine, intestinal worms, hemorrhoid, piles, diarrhea, heartache as well as various infections and it has been concluded that they have a wide usage area as an alternative treatment method [7]. The purpose of the present study was to investigate the antimicrobial and antioxidant activity of E. emiliae.…”

Section: Introductionmentioning

confidence: 93%

Antimicrobial and Antioxidant activity of Echinops emiliae (Asteraceae)

Şapci

Vural

Özcan

2017

International Journal of Secondary Metabolite

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Abstract:The aim of this study was to investigate the antimicrobial and antioxidant activities of different extracts from Echinops emiliae Schwarz ex P. H. Davis. Antimicrobial activity was estimated against several common human pathogenic bacterial strains using the agar disc diffusion and minimal inhibitory concentration assays. Antioxidant activity was evaluated using the total flavanoid and total phenolic content methods. On the light of these experiments, E. emiliae would seem to be an important natural antioxidant. Antimicrobial and antioxidant of E. emiliae have not been reported up to now. The results of this study obviously reported that the antimicrobial and antifungal activity could be change with used extracts. Also, the micro dilution method was more sensitive than disk diffusion. This study is first report on the biological activity of E. emiliae as regarded endemic species from Turkey. The results show that E. emiliae could use in the treatment of some illness.

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“…Os estudos relativos à avaliação moluscicida de vegetais, que obtiveram resultados positivos de extratos, sugerem que a atividade tóxica das plantas se deve à presença de metabólitos secundários como taninos, saponinas, terpenoides, esteroides e flavonoides, dentre outros (Chifundera et al, 1993;Rey, 2001;Hymete et al, 2005). Treyvaud et al (2000) relaciona a atividade moluscicida de Phytolacca icosandra às saponinas isoladas do extrato metanólico e aquoso das bagas desse vegetal, as quais apresentaram atividade para B. glabrata em concentrações de 200 e 25 ppm.…”

Section: Consideraçõesunclassified

Atividade moluscicida de plantas: uma alternativa profilática

Cantanhêde¹,

Marques²,

Silva-Souza³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: Uma das formas de combate a helmintos que possuem moluscos em seu ciclo biológico é o controle da população malacológica. A tentativa de combater os criadouros naturais de hospedeiros intermediários, através de moluscicidas, tem sido uma das formas almejadas para a redução da incidência de enfermidades, como as esquistossomoses e fascioloses. Essa medida epidemiológica tem se concretizado através da utilização dos moluscicidas sintéticos que, dentre outras desvantagens, trazem danos ao ecossistema. Visando a obtenção de novos compostos, os estudos sobre a potencialidade de produtos naturais moluscicidas têm crescido consideravelmente. Alguns pesquisadores apontam os moluscicidas vegetais como fontes alternativas para o tratamento profilático de parasitoses. Tendo em vista a abrangência, endemicidade e relevância, este trabalho revela um maior enfoque à atividade moluscicida de plantas relacionada às esquistossomíases. Unitermos: moluscicida, vegetal, esquistossomose.ABSTRACT: "Plant molluscicidal activity: a prophylactic alternative". An effective way to combat helminthes having mollusk in their life cycle is by controlling their population. The attempt to battle the natural breeding of intermediary hosts through molluscicides has been the targeted approach to reduce the incidence of such diseases as schistosomiasis and fascioloses. This epidemiological measure has been performed using synthetic molluscicides which, among other drawbacks, cause damages to the ecosystem. In order to obtain new compounds, studies on the potential of natural molluscicides products are increasing. Researchers draw attention to molluscicides plants as alternative sources for the prophylactic management of parasitoses. In view of the scope, significance and endemism, the present work highlights plant activities related to schistosomiasis.

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Screening of Echinops ellenbeckii and Echinops longisetus for biological activities and chemical constituents

Cited by 46 publications

References 7 publications

Essential‐Oil Composition, Antileishmanial, and Toxicity Study of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia

Essential‐Oil Composition, Antileishmanial, and Toxicity Study of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia

Antimicrobial and Antioxidant activity of Echinops emiliae (Asteraceae)

Atividade moluscicida de plantas: uma alternativa profilática

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